Analyzing 19 Texts Blitarrl STN-DBS For Parkinson’S Disease

Background:Parkinson’s disease is a common and complex neurological disorder. Deep brain stimulation was current used for treatment PD.The treatment of Parkinson’s disease were combined medication and surgery, also need to neurology, psychiatry, rehabilitation department coordination, etc.Major surgery method was deep brain stimulation(DBS).Objective s:This study analysis of 19 patients with Parkinson’s disease on bilateral STN-DBS, aims to summarize the operation experience, observation on bilateral STN-DBS surgery for patients with symptoms improve and the drug dose reduce.Methods:We evaluated 19 patients with advanced PD after bilateral STN DBS.The patients were assessed using Unified Parkinson’s Disease Rating Scale (UPDRS) in medication-on and medication-off conditions, both preoperatively and postoperatively.Results:A total of 19 patients implanted electrodes 38 root. Stimulator implanted position and preoperative planning target deviation were less than 0.5 mm.l patient completed 1 year follow-up,8 patients completed 6 months of follow-up, 5 patients complete 3 months follow-up,5 patients complete 1 months follow-up. Patients with no exit or aborted.1 patients postoperative found cortex small hematoma puncture point, the rest of the patients with no surgery related complications occurred. After one month 19 patients UPDRS-III score (medication-on) average improved 69.85+ 11.80%;After 3 months 14 patients UPDRS-Ⅲ score (medication-on) improve 67.36 ±15.22%;After 6 months 9 patients improve 71.83±13.93%;Postoperative follow-up of 1 year patients improved 71.42%.Postoperative antiparkinsonian dose levodopa reduce average 150 mg.Conclusions:(1) Through strict preoperative evaluation, the preoperative localization, CLP physical detection, the bilateral STN-DBS surgery were safety. (2) Bilateral STN-DBS surgery could improve symptoms of PD patients with movement and motion complications. (3) STN-DBS can decrease some patients dose of medication.