The Assessment Of The Degree Of Hepatic Fibrosis In Schistosomiasis Japonica By Contrast-enhanced Ultrasound

Schistosomiasis has regional characteristic, JingZhou city, HuBei province belonging to the middle and lower reaches of the Yangtze river region, has the high incidence of schistosomiasis. Schistosomiasis chronic phase is given priority to with the development of liver fibrosis, thus the dangers of schistosomiasis is great, which cause serious damage to the farmers’health. Ultrasonic imaging is carried out in recent years, new technology, not only can judge microcirculation blood supply changes, and also improves the resolution of gray-scale imaging contrast, improve the ability of qualitative diagnosis. We look at schistosomiasis liver fibrosis by contrast-enhanced ultrasound liver hemodynamic changes, to evaluate schistosomiasis liver fibrosis degree.Object:Preliminary study on the clinical significance and application value of contrast-enhanced ultrasound in the analysis and evaluation of the degree of liver fibrosis of schistosomiasisMethods:1.40 patients who were diagnosed by clinical examination of schistosomiasis, excluding other disease may cause liver changes, of which male 23 cases, female 17 cases. And establish a normal control group of 20 cases,10 cases of male and female.2.40 patients were selected to do conventional ultrasonic test, from which they can be divided into grade 0 to grade III, referring to the ultrasonic diagnosis of schistosomiasis Advisory Council held in Cairo, October 1990 by WHO/TDR, developed schistosomiasis liver grading standard, which referred to ultrasonic echo of liver parenchyma changes. And homologous group 0, group I, group II and group III will be. We had 15 cases of grade 0,11 cases of grade I,9 cases of grade II,5 cases of grade III.3.40 cases of patients and 20 cases of normal control group were treated by 2ml ultrasound contrast agent, the dynamic contrast images were collected more than 2 minutes, and the frequency of 8 frames per second in DICOM format was stored in the instrument’s hard disk. Through the playback of recorded video, recording the ultrasound contrast agent reach the hepatic artery (HAAT) and portal vein (PVAT), hepatic vein (HVAT) time with visual method to calculate hepatic arteriovenous transit time (HA-HVTT=HVAT-HAAT), portal vein and hepatic vein transit time (PV-HVTT=HVAT-PVAT).4. To compare the correlation between cases of patients and cases of normal control group such as HAAT, PVAT, HVAT, PV-HVTT, HA-HVTT.5. To compare the correlation between four groups patients such as HAAT, PVAT, HVAT, PV-HVTT, HA-HVTT.Results:1. The difference of the HAAT, PVATT between the case group and the normal control group was not significant (P>0.05);2. Level 0, gradeⅠgroup contrast to hepatic vein imaging time (HVAT) compared with control group, the time similar or slightly change, but there was no statistically significant difference (P>0.05));Class Ⅱ group, the level Ⅲ group contrast to hepatic vein imaging time (HVAT) compared with control group, the shorter time, the difference was statistically significant P<0.05);3. Level 0, grade Ⅰ group contrast agent transit time (PV-HVTT, HA-HVTT) compared with control group, the time slightly shorter, but there was no statistically significant difference (P>0.05); Class Ⅱgroup, the level Ⅲ group contrast agent transit time (PV-HVTT, HA-HVTT) compared with control group, the shorter time, the difference was statistically significant (P<0.05);4. Class Ⅰ group contrast agent transit time (PV-HVTT, HA-HVTT) compared with group level 0, slightly shorter time, but there was no statistically significant difference (P>0.05);Class Ⅱgroup contrast agent transit time (PV-HVTT, HA-HVTT) compared with the level 0, grade Ⅰ, shorter time, the difference was statistically significant ((P<0.05);Level Ⅲ contrast agent transit time (PV-HVTT, HA-HVTT) with a level 0 group, the classⅠand class Ⅱgroup, compared to a shorter time, the difference was statistically significant ((P<0.05);Conclusion:1. Contrast to hepatic artery (HAAT) and portal vein in time (PVAT) no obvious correlation with schistosomiasis liver fibrosis degree..2. Contrast to hepatic vein time (HVAT), contrast agent transit time (PV-HVTT, HA-HVTT) and schistosomiasis liver fibrosis degree has higher correlation; Contrast to hepatic vein time (HVAT), contrast agent transit time (PV-HVTT, HA-HVTT) shorten with schistosomiasis liver fibrosis degree aggravating, negatively correlated.3. In ultrasonic imaging quantitative parameters, the contrast agent to hepatic vein time (HVAT), contrast agent transit time (PV-HVTT, HA-HVTT) as a quantitative index, used to judge the schistosomiasis liver fibrosis degree, the classification of schistosomiasis liver fibrosis has certain clinical reference value, can be used for dynamic analysis and evaluation of schistosomiasis liver fibrosis degree especially moderately severe liver fibrosis.