| ObjectiveBy analyzing the difference between the common syndrome types of Traditional Chinese Medicine (TCM) and quality of life or clinical evaluation indexes in the patients of ankylosing spondylitis(AS), we can take the corresponding individual targeted treatment program from multi-angle and multi-level to improve the efficacy of TCM clinical treatment and the quality of their lives in the future. At the same time, in order to establish a set of AS evaluation scale which has the clinical characteristics of TCM on the quality of life, we can provide a certain clinical basis.MethodsIn this study, strictly in accordance with the inclusion criteria and exclusion criteria we selected 92 AS patients whose TCM syndrome types were diagnosed by 2 or 3 director of Chinese medicine. Then the researcher inquired and recorded the patients’demographic data, quality of life(QOL) score and clinical evaluation index(including BASDAI score, BASFI score, VAS score, C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), red blood cell(RBC), hemameba(WBC), platelet(PLT)), with the statistical methods to compare the difference between TCM syndrome types and quality of life or clinical index in AS patients.Results1. Comparison of TCM syndrome type with QOL score in AS patients:The changes of Physical Functioning(PF), Role-Physical(RP), Bodily Pain(BP), Vitality(VT), Mental Health(MH) and comprehensive score were statistically significant among the type groups(P＜0.05), while the changes of General Health(GH), Social Functioning(SF) and Role-Emotional(RE) score were not significant difference(P＞0.05).In PF dimension, there were statistically significant difference between the dampness-heat blockage syndrome(type 1) and cold-dampness blockage syndrome (type 2), phlegm-stasis blockage syndrome (type 3), Liver and kidney deficiency syndrome (type 4) (P＜0.0083), the PF score of type 1 was less than the other groups. In RP dimension, the difference between type 1 and type 2&3 showed statistically significant(P<0.0083), the RP score of typel was significantly lower than those of the above two groups. In BP dimension, there were statistically significant difference between type 1 and type 4(P<0.0083), the BP score of type 1 was significantly lower than it. In VT and MH dimension, the difference between type 1 and type 3 showed statistically significant (P＜0.0083), the VT and MH scores of type 1 were Less than type 3. In the comprehensive score aspect, there were statistically significant difference between type 1 and type 3&4(P<0.0083), the score of type 1 was less than those of the above two types.2. Comparison of TCM syndrome type with clinical evaluation indexes in AS patients:The changes of BASFI score, BASDAI score, VAS total pain and VAS night pain were statistically significant among the type groups(P<0.05), while the changes of VAS general evaluation was not significant difference(P>0.05).In terms of BASFI score, the difference between type 1 and the other types showed statistically significant(P<0.05), the BASFI score of type 1 was obvious above them. In terms of BASDAI score, there were statistically significant difference between type 1 and the other types, type 2 and type 4(P＜0.05), the BASDAI score of type 1 was supreme among them and the type 2 was higher than type 4. In aspects of VAS total pain and VAS night pain, the difference between type 4 and type 1&2&3 showed statistically significant(P＜0.05), both of type 4 were the obviously lowest among them.3. Comparison of TCM syndrome type with clinical objective indexes in AS patients:The changes of RBC and WBC indexes were not statistically significant among the type groups (P＞0.05), while the changes of ESR, CRP and PLT indexes showed significant difference(P<0.05).In terms of ESR and CRP indexes, the difference between type 1 and type 4 showed statistically significant (P＜0.0083), both of type 1 were higher than type 4. In aspect of PLT index, there were statistically significant difference between type 4 and the other types(P<0.05), those of type 4 was the lowest among them. ConclusionThe Physical Functioning, Role-Physical, Bodily Pain, Vitality, Mental Health, BASFI and BASDAI score had the greatest impact on the patients with dampness-heat blockage syndrome. Meanwhile the ESR and CRP indexes were significantly increased. The patients with liver and kidney deficiency syndrome, whose influence on the vitality and mental health dimension was prominent. But the effect of pain were the most mild and the ESR and CRP indexes were mostly normal. The patients with cold-dampness blockage syndrome and phlegm-stasis blockage syndrome, whose survival quality score indexes between dampness-heat blockage syndrome and liver and kidney deficiency syndrome, but both at night pain prominent. The normal range of PLT index was slightly high in the phlegm-stasis blockage syndrome. Therefore, the results of this study can provide more targeted, standardized and individualized treatment ideas, so as to improve the clinical efficacy of TCM and the quality of life of patients with AS. |
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