| Objective: This study aims to further explore the change of serum cardiac troponin I and plasma brain natriuretic petide combined with Tei Index in neonatal asphyxia with myocardial injury, and analyzed its clinical value in neonatal asphyxia with myocardial injury.Methods: 90 cases of term newborn were randomly selected, between January 2013 to December 2015, of which 60 cases of asphyxia with myocardial injury as the observation group and 30 cases of normal newborns as control group, according to the degree of asphyxia observation group was divided into mild asphyxia group(30 cases) and severe asphyxia group(30 cases). Observation group were detected in the acute stage(within 24 h after birth) and convalescence(days 7d) cTnⅠ,CK-MB,plasma brain natriuretic peptide level in serum,EF and Tei index. Compare observation group and the control group, and analyzed the relationship between BNP and cTnⅠ, CK-MB,Tei index.Results: The serum cTnⅠ, CK-MB, plasma BNP levels and Tei index of observation group in acute stage was significantly higher than the control group(P<0.05). EF was no significant difference in three group(P>0.05). The serum cTnⅠ, CK-MB, plasma BNP levels and Tei index of severe asphyxia group in acute stage was significantly higher than mild asphyxia group(P<0.05). The serum cTnⅠ, CK-MB, plasma BNP levels and Tei index of observation group was significantly decreased at comparison between myocardial injury in convalescent and acute stage(P<0.05). Plasma BNP level was positively correlated with the serum cTnⅠ(r=0.762,P<0.05), CK-MB(r=0.483,P<0.05), and Tei index(r=0.540,P<0.05) in mild asphyxia group. Plasma BNP level was positively correlated with the serum cTnⅠ(r=0.612,P<0.05), CK-MB(r=0.729,P<0.05), and Tei index(r=0.680,P<0.05) in severe asphyxia group.Conclusion: The combined detection of serum cTnⅠ, plasma BNP and cardiac Tei index may be an early and comprehensive assessment of neonatal asphyxia with myocardial injury and cardiac function, assessment of efficacy. |
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