Soy Protein Consumption Versus Animal Protein Consumption For Chronic Kidney Disease

Objective To compare the effects of soy protein and animal protein on plasma lipid status, renal function and proteinuria in chronic kidney disease patients.Methods Articles in English and Chinese were searched from PubMed, Cochrane library, Web of SCI, EMbase and Randomized controlled trials on the treatment with soy protein and animal protein in chronic kidney disease were included. The trials should contain the data of total cholesterol and serum triglyceride concentrations and the treatment duration should last no less than 7 weeks. The quality of the trials was evaluated and data were analyzed with the method of Meta-analysis using the software of RevMan 5.3.Results Four randomized controlled trials were met the inclusive criteria and entered into random effect model. Compared with animal protein, soybean protein significantly decreased the levels of LDL-c [weight mean difference (SMD)=-8.92,95%confidence interval (CI)-14.13 to -3.71, P<0.05], urine creatinine (WMD=-0.39,95%CI -0.53 to -0.26, P<0.05),proteinuria (SMD=-82.42,95%CI-106.92 to-57.93, P<0.05).There were no significant difference in total cholesterol (SMD=-8.30,95%CI-24.20 to 7.59, P>0.05) and triglyceride (SSMD=-2.71,95%CI -25.31 to 19.88, P>0.05).Conclusions Compared with animal protein, soy protein is able to decrease the levels of LDL-c, serum creatinine and proteinuria, but has no effect of total cholesterol and triglyceride.