| Objective: The purpose of this study was to explore the safety and efficacy of transabdominal radiofrequency renal denervation in a Beagle model to explore a new way of renal sympathetic denervation.Methods: Ten neurogenic hypertensive beagle dogs were divided into intervention group(n=6) which received renal sympathetic denervation by transabdominal radiofrequency and control group(n =4) only received open surgery operation without radiofrequency. Arterial pressure, PRA and AngⅡ were detected before and 2,4,6 weeks after operation. Renal function were also detected.Results: In intervention group, arterial pressure decreased from(126.09±8.84)mmHg before operation to(115.82±9.93)mmHg(P=0.008),(118.55±6.25)mmHg(P=0.07),(113.91±6.76)mm Hg(P=0.002),(107.45±6.07)mmHg(P<0.001) respectively at 2, 4, 6, 8 weeks after operation while PRA and AngⅡ decreased simultaneously. However, such as creatinine and blood urea nitrogen reflecting the renal function remained unchanged post procedure(P>0.05). The renoarteriography and pathological examination showed no obvious abnormalities.Conclusion: Transabdominal radiofrequency renal denervation is safe and results in substantial and sustained blood-pressure reduction in beagle dog model. |
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