| Objective:To observe the therapeutic effect and safety of "Chai Hu Shu Gan San" on myocardial bridge,to seek the effect prescription for the treatment of myocardial bridge, provide new ideas to expand the indication of Liver Qi painkillers at the same time.Methods:60 cases of patients diagnosed as coronary myocardial bridge in our hospital were selected, and 30 patients with inclusion and exclusion criteria were divided into the control group and the treatment group according to the principle of random contro-1.The control group was treated with metoprolol sustained-release tablets 23.75-47.5mg once daily (verapamil sustained release tablets 0.24 instead of beta blocker contraindic-ations,once a day),and heart rate control in 55-65 times/min.The treatment group were treated with traditional Chinese medicine "Chai Hu Shu Gan San".The course of treat-ment for 6 weeks, the clinical curativeeffect, ECG and TCM syndrome score of two groups before and after treatment wereobserved, and the adverse reactions were observ-ed.Results:1.Control group, the average age (60.77±7.68), including 21 males,9females, with the hypertension patient 22 people, diabetes 5 people, combined hyperlipidemia 5; the mean age of the treatment group average age(58.67±9.15), including 17 males,13 fem-ales, with the hypertension patient 15people,4people with diabetes, diabetes combined with hyperlipidemia 5.There was no significant difference in age, sex composition and distribution of disease degree between the two groups (P>0.05).2.Control group in the symptoms of angina pectoris curative effect evaluation mar-kedly effective in 2 cases (6.67%), effective in 23 cases (76.67%),4 patients (13.3 3%) were ineffective and aggravated in 1 cases (3.33%). The total effective rate was 83.34%. The treatment group markedly effective in 17 cases (56.67%), effective in 12 cases (40.00%), invalid 1 case (3.33%), increased 0 (0.00%), effective rate was 96.6 7%.There was significant difference between the two groups (z=-4.11, P<0.05),and the treatment group was more effective in reducing the clinical symptoms of angina pector-is.3.The control group in ECG efficacy evaluation in effective in 1 cases (3.33%), effective in 1 cases (3.33%), invalid in 27 cases (90.00%), increased in 1 cases (3.3 3%). The total effective rate of 6.66%; treatment group markedly effective in 5 cases (16.67%), effective in 3 cases (10.00%), ineffective in 22 cases (73.33%), increased 0 (0%), effective rate is 26.67%.There was significant difference between the two groups (z=-2.24, P<0.05), and the treatment group was more effective in improving the ECG.4.The control group in the TCM syndrome integral efficacy evaluation.7 cases were cured (23.33%), effective in 21 cases (70.00%), invalid in 1 cases (3.33%), aggr-avated cases (3.33%), the effective rate of 93.33%.The treatment group was markedly effective in 22 cases (73.33%), effective in 7 cases (23.33%), invalid 1 case (3.33%), increased 0(0.00%), effective rate was 96.66%.There was significant difference between the two groups (z=-3.70, P<0.05), and the treatment group was more effective in redu-cing TCM syndrome score.5.There were not occurred cardiovascular clinical event level drug adverse events in the clinical trials of 5 groups in this topic, does not have statistical significance.Conclusions:1."Chai Hu Shu Gan San"for the treatment of qi stagnation and blood stasis type of coronary myocardial bridge can relieve clinical symptoms, improve the ECG, decr-ease of TCM syndrome integral, better than westernmedicine control group.2.The group of "Chai Hu Shu Gan San"formula rigorous, closely linked to the path-ogenesis, in the treatment of observation without obvious adverse reactions and side effects, so it is safe. |
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