Expression And Clinical Significance Of IGF-IR And STAT3 In Prostate Cancer

Objective:To study the expression of insulin like growth factor I receptor (IGF-IR) and signal transduction and transcription activation factor 3(STAT3) in prostate cancer (PCa) and benign prostatic hyperplasia (BPH), exploring the role of IGF-IR and STAT3 in the occurrence, development and metastasis of prostate cancer,Further servicing for the clinical diagnosis and treatment,and providing a new approach for the targeted therapy of prostate cancer.Method:The expression of STAT3 and IGF-IR in paraffin sections of 38 cases of prostate cancer and 15 cases of benign prostatic hyperplasia tissues were detected by immunohistochemical staining SP method. To analyze the difference between IGF-IR and STAT3 protein expression in prostate cancer and benign prostatic hyperplasia, as well as its relationship with clinical pathological parameters of prostate cancer. All results were analysed by statistical software SPSS20.0 and statistical significance was defined as P values less than 0.05.Results:1.The positive expression rate of IGF-IR in prostate cancer tissues was 86.84%(33/38); the positive expression rate of IGF-IR in benign prostatic hyperplasia was 53.33% (8/15), and the difference was statistically significant (P<0.05). The relationship between IGF-IR expression and clinical pathological parameters of prostate cancer:(1)pathological grade:the positive expression rate of middle and high differentiation group and differential/undifferentiated group was 70%(7/10),92.86% (26/28), and the difference was not statistically significant (P>0.05). (2) TNM clinical stage:the positive expression rate was 66.67%(8/12) in T1-T2 period and the T3-T4 period was 96.15%(25/26),and there was significant difference between the two groups (P<0.05).2. The positive expression rate of STAT3 in prostate cancer tissues was 84.21% (32/38); the positive expression rate of IGF-IR in benign prostatic hyperplasia was 33.33%(5/15), and the difference was statistically significant (P<0.05). The relationship between STAT3 expression and clinical pathological parameters of prostate cancer:(1)pathological grade:the positive expression rate of middle and high differentiation group and differential/undifferentiated group was 60.00% (6/10),92.86%(26/28), and the difference was statistically significant (P<0.05). (2) TNM clinical stage:the positive expression rate was 50.00%(6/12) in T1-T2 period and the T3-T4 period was 100%(T3-T4),and there was significant difference between the two groups (P<0.05).3.In the38 cases of prostate cancer, there were 30 cases of positive expression of STAT3 and IGF-IR, By Spearman correlation analysis, the expression of IGF-IR was positively correlated with STAT3 expression (r=0.615, P<0.01).Conclusion:1.The positive expression rate of IGF-IR and STAT3 in prostate cancer was significantly stronger than that in benign prostatic hyperplasia, and the difference was statistically significant.2.The positive expression rate of IGF-IR in prostate cancer patients with different TNM clinical stage had statistical difference, there was no significant difference between different pathological grades; the positive expression rate of STAT3 in prostate cancer patients with different pathological grades was statistically significant difference, but there was no significant difference between TNM clinical staging.3. The expression of IGF-IR and STAT3 in prostate cancer tissues have positive correlation, IGF-IR and STAT3 protein molecules may via the same signal transduction pathway, mediating the occurrence, progression and migration of prostate cancer.