Study On Default Mode Network Of Normal Adult That Lived In High Altitude And Sea Level By BOLD-fMRI

Objective: Purpose:To explore the changes of default mode network(DMN)in normal adult that lived in high altitude and sea level by blood-oxygen level dependent fMRI,to investigate the influence of high altitude hypoxia on the brain.Methods :21 cases of normal adult that lived in high altitude and age, sex matched 20 cases of normal adult lived in sea level underwent whole brain scan, and EPI images were acquired. The difference in DMN between the two groups was analyzed by defining posterior cingulate cortex(PCC) as seed region. Group comparison using single sample t test, the comparison between groups using two sample t test.Result:DMN analysis: in the resting state①,the range of activated brain areas of high altitude and sea-level group are similar,the range is consistent; ② compared with sea level group, high altitude group enhanced brain regions connected with the posterior cingulate cortex is: left anterior cingulate gyrus, right medial superior frontal gyrus, bilateral middle frontal gyrus and right putamen, while reduced connection with the posterior cingulate cortex: the left cerebellum VIII area.Conclusion:Compared with the sea level group, there are many different brain areas in resting state.These differences may be related to the influence of the high altitude hypoxia environment on the brain and the environmental adaptability of high altitude residents.This study demonstrated the cerebral and functional modifications with chronic high altitude hypoxia.Resting state functional magnetic resonance imaging can provide a non-invasive and reproducible imaging basis for the study of the effects of high altitude hypoxia on the brain and the occurrence of high altitude brain disease.