Clinical Research On Analgesic Effect Of Pentazocine And Ketorolac Tromethamine In General Anesthesia

Objective:To evaluate the efficacy and safety of pentazocine and ketorolac tromethamine in preventing and curing the postoperative acute pain in remifentanil balanced anesthesia.Methods:Sixty patients undergoing posterior lumbar interbody fusion selective surgery were randomly assigned to be intravenously injected(1) saline with a equal dose;(2)pentazocine0.5mg/kg;(3)ketorolac tromethamine 0.5mg/kg,S group,P group, A group respectively,at about 30 minutes before the end of surgery.The patient’s respiratory recovery time,recovery time,extubation time,operation time were measured and recorded after we stopped intravenous infusion of propofol and remifentanil with micro-infusion pump; The patient’s vital signs,such as, mean arterial pressure and heart rate also were measured and recorded after extubation;The patient’s verbal rating scales(VRS) were assessed at 5minutes,10 minutes,15 minutes,30 minutes respectively after extubation;The number of cases of requiring postoperative analgesia and respiratory depression, irritability, nausea and vomiting was also needed to be recored.Results:There was no statistically significant difference between three groups of patients’ respiratory recovery time,recovery time,extubation time,operation time and mean arterial pressure and heart rate after extubation(P>0.05).At 5 minutes,the VRS score in S group was higher than that in A group(P<0.05) and the VRS scores comparison between P groupand S group, A group respectively is not statistically significant(P>0.05).P group and A group’s VRS scores,indicating no statistical significance(P>0.05) when compared,were both lower than S group’s(P<0.05) at 10 minutes,15 minutes,30 minutes respectively after extubation.There was no statistically significant difference between three groups of patients’ analgesia cases and the incidence of irritability, nausea and vomiting, respiratory depression(P>0.05).Conclusions:Pentazocine and ketorolac tromethamine,intravenously injected 30 minutes before surgey was over, can safely and effectively prevent and cure the postoperative acute pain in remifentanil balanced with propofol anesthesia without affecting the patient’s extubation and recovery and obvious adverse reactions.In addition, there was not significant difference in the comparison of the analgesic effect between the pentazocine and ketorolac tromethamine in remifentanil balanced anesthesia in clinic.