Systematic Review Of Huoxuehuayu Intervention Effectiveness And Safety Of After PCI Of Coronary Heart Disease Patients

Objective: To evaluate the Huoxuehuayu intervention effectiveness and safety of coronary heart disease patients after PCI by the method of the Systematic Review.Methods: This study was searched from the Cochrane Library, PubMed, CNKI, CBM, VIP,and Wanfang database according to the search strategy, ending in August 31, 2015. And it was manual seaching. Included studies was the randomized controlled clinical study, the research object was coronary heart disease patients received PCI, the treatment group must be based on Huoxuehuayu method interventions, the control group was routine treatment with or without placebo, methodological quality of the studies was the modified Jadad scale score more than 4points. RevMan5.2 software was used for statistical analysis of included studies.Results: We included 29 randomized controlled trials, including 2 articles for English, a total of 3412 patients, 1599 cases in test group, 1570 cases in the control group. Meta-analysis showed: Huoxuehuayu which combined with conventional western medicine treatment significantly reduced the incidence of restenosis, recurrence of angina, myocardial infarction and revascularization, but on the death, reduce postoperative heart failure and readmission number was no statistical difference between the two groups. Huoxuehuayu which combined with conventional western medicine treatment significantly improved the effect of Chinese medicine syndrome and improved the symptoms of patients with traditional Chinese Medicine syndrome, blood stasis syndrome, SAQ. Huoxuehuayu which combined with conventional western medicine treatment significantly improved NYHA I[RR=1.18,(95%CI:1.03,1.35), P=0.02], but in improvement of NYHA II and NYHA III was no statistical difference between the two groups. Huoxuehuayu which combined with conventional western medicine treatment significantly enhanced LVEF[MD=4.23,(95%CI:1.96,6.50), P=0.0003]. Huoxuehuayu which combined with conventional western medicine treatment significantly reduced hs-CRP[MD=-1.47,(95%CI:-2.61,-0.33), P=0.01].Huoxuehuayu which combined with conventional western medicine treatment significantly reduced the content of TC and LDL-C, but in the effects on TG and HDL-C were no statistical difference between the two groups. Huoxuehuayu which combined with conventional western medicine treatment in the treatment of coronary heart disease with PCI has goodsafety[OR=0.37,(95%CI:0.17,0.83), P=0.02].Sensitivity analysis: The stability of each observation index was good, and the conclusion was good. Publication bias: restenosis, TCM efficacy and recurrence of angina were the basic symmetric graph, indicating that there were no publication bias.Conclusion: Huoxuehuayu which combined with conventional western medicine treatment intervention of coronary heart disease patients after PCI has advantages compared with routine western medicine with or without the placebo treatment results, could reduce the number of restenosis, recurrence of angina, myocardial infarction and revascularization,improve the overall efficacy of TCM, blood stasis symptoms, TCM syndrome, heart function,and LVEF, reduce the content of cholesterol total, low density lipoprotein and C reactive protein,and have good safety. This research provides an effective and reliable treatment for coronary heart disease in patients with PCI, provide more choices for clinical.