Brain Function Of F Mri On Low Back Pain Using Electroacupuncture

Objective:Using f MRI technology to explore the Activate or inhibit brain regions when electroacupuncture stimulate acupoints of Dachang Shu and Weizhong of the normal person,to analyze the differences of resting-state brain network between patients with low back pain and normal person or observe the changes of resting-state brain network before and after electroacupuncture treatment,discussing the brain mechanism of the patients with low back pain by electroacupuncture. Methods:20 healthy volunteers and 20 patients with low back pain met the inclusion criteria,They were divided into normal group and treatment group.The normal group was collected f MRI dates of resting-state and task-state f MRI dates of blocks design patterns by stimulated Dachang Shu and Weizhong acupoints. The treatment group was collected f MRI dates of the first time resting-state on the same day. We collected f MRI date of the second time resting-state,when they were treated two courses by acupuncture physicians stimulating main acupoints of Dachang Shu and Weizhong continuing. SPM software was used to analyze the date. Resultes:1. Activated brain regions of normal group Task-state were left lateral sulcus, left Central sulcus, right Supramarginal gyrus, right prefrontal medial frontal gyrus, bilateral thalamus, and bilateral Insula. The inhabited brain regions were left inferior frontal gyrus, bilateral parahippocampal gyrus, right cingulate cortex abdominal segment, and right parietal.2.The changes of the brain network on patients compared with normal(1)The brain regions of enhanced functional connectivity,in left: Parahippocampal gyrus and Amygdala, Superior occipital gyrus and Middle occipital gyrus, Cuneus and Lingual gyrus;in right Olfactory cortex and frontal gyrus,Angular gyrus and Rolandic operculum and Inferior frontal gyrus.(2)The brain regions of function connection decreased,in between left Parahippocampal gyrus and Fusiform gyrus, Olfactory cortex and Anterior cingulate and paracingulate gyri,Posterior cingulate gyrus and dorsolateral frontal gyrus and Middle occipital gyrus, Inferior temporal gyrus and Middle temporal gyrus;in right :Precuneus and Posterior cingulate gyrus and Cuneus, Paracentral lobule and Superior parietal gyrus,Anterior cingulate gyrus and Middle frontal gyrus, medial Superior frontal gyrus and Middle temporal gyrus.(3)The new inhabited brain regions,in left Middle occipital gyrus and Median cingulate and paracingulate gyri;in right :Precentral gyrus and dorsolateral frontal gyrus,Anterior cingulate gurus and Superior occipital gyrus, dorsolateral Superior frontal gyrus and Superior temporal gyrus.(4)The brain regions of decreased correlation, in left :Supramarginal gyrus and dorsolateral frontal gyrus, Superior parietal gyrus and medial Superior frontal gyrus;in right: Precentral gyrus and dorsolateral Middle frontal gyrus.3.The changes of brain network of LBP after treatment(1)The brain regions of enhanced functional connectivity,in left: Middle frontal gyrus and Angular gyrus, Parahippocampal gyrus and Fusiform gyrus, Olfactory cortex and triangular part Inferior frontal gyrus, Heschl gyrus and Postcentral gyrus,Median cingulate and paracingulate gyri and Superior temporal gyrus;in right :Postcentral gyrus and Paracentral lobule, Insula and Supramarginal gyrus, Posterior cingulate gyrus and Precuneus, Parahippocampal gyrus and Fusiform gyrus, Insula and Supplementary motor area and Inferior frontal gyrus, triangular part, Posterior cingulate gyrus and Precuneus, Parahippocampal gyrus and Fusiform gyrus, orbital part Middle frontal gyrus and Anterior cingulate gyrus and dorsolateral Superior frontal gyrus.(2)Brain regions of function connection decrease, in left :Cuneus and Lingual gyrus, Parahippocampal gyrus and Amygdala, Anterior cingulate and paracingulate gyri and Middle frontal gyrus, Supplementary motor area and Temporal pole: superior temporal gyrus, Angular gyrus and opercular part Inferior frontal gyrus; in right :Cuneus and Inferior occipital gyrus.(3)Brain regions of degative inhabition,in left: Superior parietal gyrus and Posterior cingulate gyrus, Rolandic operculum and dorsolateral Superior frontal gyrus, Middle occipital gyrus and Superior temporal gyrus and Median cingulate and paracingulate gyri, Insula and Calcarine fissure and surrounding cortex;in right: Anterior cingulate gyrus and Middle occipital gyrus, Postcentral gyrus and Superior frontal gyrus, Rolandic operculum and medial Superior frontal gyrus.4.By analyzing the patients’ topology before and after treatment, the results reminder that after treatment patients’ whole brain information transmission efficiency and information exchange of brain regions local were improved after treatment. Conclusions:1.Electroacupuncture stimulating Dachang Shu and Weizhong of Volunteer’s acupoint could activate many brain regions, which played role of neuromodulation analgesic function.2.There was obviously significant difference of the default network and pain network on compared patients group with normal control group.It indicated that Low back pain could also affect the brain function.3.Many Brain regions of the default network and pain network,function connection could restore after treated after with acupuncture.It indicated that acupuncture therapy could improve the function of the default and pain network.4.The delay effects of acupuncture therapy treated low back pain was brain function connections among of linbic-paralimbic-neocortical-network were enhanced.