| Objective:This study aims to observe the effect of Peishiruanganxiaopi pills on prolonging progress-free survival time and improving living quality of hepatocellular carcinoma after transcatheter arterial chemoembolization in patients, to evaluate the effectiveness and safety of Peishiruanganxiaopi pills objectively which treated hepatocellular carcinoma and to further enrich ways of intergrated Traditional Chinese and Western medicine for hepatocellular carcinoma in clinic. Methods:During the time February 2014 to May 2015, 48 hepatocellular carcinoma cases of Gansu Province Tumor hospital which are accordance with the inclusive criteria were collected. The inclusive 48 cases were divided into treatment group and control group randomly, 24 cases in each group, this two group has no significant difference(P>0.05) in age, gender, neoplasm staging and liver function Child-Pugh classification. The control group was treated with only basic western medicine methods, the treatment group was treated with basic western medicine methods and oral ingest of Peishiruanganxiaopi pills. According to established sheme, clinical treatment and observation were given to the two groups, 2 courses of treatment and 6 months of follow-up. Observe the change of alpha-fetoprotein, liver function and life quality before and after treatment. Record the progression-free survival time and half-year survival rate of the two groups, and mornitor bone marrow suppression, renal function, bladder function and adverse events at the same time, to evaluate the safety of Peishiruanganxiaopi pills. Results:The treatment group and control group had 1 and 2 cases dropping off respectively, 45 cases were involved in the statistic analysis of results, among them, 23 cases are treatment group and 22 cases are control group. The results show that:(1) The median progression-free survival time is 145 days of the treatment group and 120 days of the control group( P<0.05), the treatment group was superior to control group, indicate that the combination of Peishiruanganxiaopi pills and basic western medicine method is better than pure basic western medicine on prolong progression-free survival time;(2) After treatment, the serum alpha-fetoprotein has no significant difference(P>0.05), suggesting that serum alpha-fetoprotein level could not be changed in a short time by Peishiruanganxiaopi pills;(3) The changes of liver function were significiant differences in the treatment group comparing with the control group(P<0.05);(4) The treatment group enhanced more than the control group on quality of life, the difference was statically significant.(P<0.05);(5)Safety evaluation: comparison between the two groups shows that there is no significant difference on myelosuppression, renal function, urine routine and stool-routine, no serious adverse event was happened, suggesting the safety of Peishiruanganxiaopi pills. Conclusion:Peishiruanganxiaopi pills can prolong the progression-free survival time of hepatocellular carcinoma after transcatheter arterial chemoembolization, improve the clinical symptoms and liver function damage, raise the life quailty of patients, and the security is good, no obvious toxicity was observed, so it has a high value on clinical application. |
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