Research Of NLR、PLR And CA-125 In The Early Diagnosis And Assessment The Prognosis Of Epithelial Ovarian Cancer

Objective: The purpose of this paper is to discuss the significance of the application which combines the NLR and the PLR with CA125 together for the early diagnosis and prognostic prognosis of epithelial ovarian cancer.Methods: 100 cases with initial ovarian carcinoma from our gynecology and obstetrics were selected as a group for the study. Selecting 100 cases of benign ovarian tumor and 100 normal women as control groups, to evaluate the NLR and PLR so as to diagnose the critical value of epithelial ovarian cancer by using ROC curves, and the joint application of critical value and CA125 is used to judge whether it has advantages of improving the susceptibility and specificity of ovarian carcinoma or not. Through follow-up study, to make sure whether there are statistical differences of NLR and PLR between recurrence group and non-recurrence group.Results: 1.The number of neutrophils in the study group and the benign tumor control group was significantly greater than that in healthy controls(P <0.05); the number of lymphocytes in the study group were much more than that in the control group(P <0.05), while the benign group and healthy controls had no significant difference(P> 0.05); platelet number of study group was significantly higher than that in healthy controls(P <0.05), whereas there is no significant difference(P> 0.05) in benign control group; NLR ratio of study group and benign control group were significantly higher than that in healthy controls(P <0.05); PLR value of the study group and benign group were significantly higher than that in healthy controls(P <0.05); CA125 of study group was significantly higher than that in healthy controls(P <0.05), benign controls and healthy controls showed no significant difference(P> 0.05).2. By using ROC curves to evaluate the NLR and PLR for diagnosing, and the critical value were 2.8 and 185. The susceptibility, specificity, positive predictive value, negative predictive value, correct index of NLR were 0.72、0.85、0.83、0.75、0.57; PLR were 0.64、0.84、0.80、0.70、0.48;The susceptibility, specificity, positive predictive value, negative predictive value, correct index of combined diagnosis of NLR and PLR were 0.79、0.84、0.83、0.80、0.63; The susceptibility, specificity, positive predictive value, negative predictive value, correct index of combined diagnosis of NLR, PLR and CA125 were 0.88、0.84、0.85、0.88、0.72.3. NLR and PLR in patients with epithelial ovarian cancer stage Ⅰ and stage Ⅱ were significantly lower than those in stage Ⅲ and stage Ⅳ(P <0.05); NLR and PLR in patients with ideal cytoreductive surgery were significantly lower than those of patients with surgery that is not ideal(P <0.05); after six months or more follow-up study, PLR and NLR in relapsing patients were significantly higher than those in patients without recurrence, this difference was statistically significant(P <0.05).Conclusion: NLR and PLR in epithelial ovarian cancer patients were significantly higher than those in healthy controls and patients with benign tumors; the diagnosis of epithelial ovarian cancer by using NLR and PLR has a high sensitivity and specificity, and the combination of NLR, PLR and the CA125 will help to improve early diagnosis of cancer in the aspects of sensitivity and specificity; ovarian cancer patients in different clinical stages have significant differences in PLR and NLR; NLR and PLR have certain significance in prediction for the postoperative recurrence and prognosis of patients...