Triterpenenes From The Indian And Thai Mangrove, Xylocarpus Moluccensis

Xylocarpus moluccensis(Meliaceae), a mangrove tree, is mainly distributed in East Africa, southeast Asia, Oceania, and other tropical areas. It was reported that this plant has been used as a folk medicine for the treatment of diarrhea, cholera, malarial fever, and the other diseases in countries of southeast Asia. Previously, phytochemical investigation of its barks and seeds yielded various types of tetranortriterpenoids, which showed broad range of biological activities, such as antifeedant, insecticidal, antibacterial, anti-inflammatory, anti-microbial, anti-malarial, and anti-tumor activities. This paper aims to investigate the tetranortriterpenes of the Indian and Thai mangrove, X. moluccensis, and seeks to find compounds with novel molecular frameworks and prominent bioactivies.The EtOAc portion from seeds of the Indian and Thai mangrove, Xylocarpus moluccensis, was submitted to silica gel, RP-C18 column chromatography, and HPLC to afford 18 compounds. The structures of these compounds were identified by MS and NMR spectroscopic analysis. They are thaimoluccepimer A(1), thaimoluccepimer B(2), 3β-hydroxy-3-decarbonyl-24-epi-piscidinol A(3), 24-epi-piscidinol A(4), odoratone(5), toonaciliatavarin E(6), sapelin E acetate(7), 6-acetoxymexicanolide(8), methyl angolensate(9), moluccensin N(10), 6-acetoxyandirolide N(11), granatumin P(12), xyloccensin L(13), godavarin A(14), moluccensin V(15), xyloccensin Q(16), xyloccensin P(17), xyloccensin T(18). Compound 3 is a new tirucallane, and compounds 1 and 2 are two new pairs of tetranortriterpene 23-epimers, whereas compound 11 is a new natural product.