The Magnetic Resonance Spectroscopy Study Of Patients With Vertebral Body Of Chronic High Altitude Disease

Objective:Using 3.0T proton magnetic resonance spectroscopy(1H-MRS) technology contrast observation of patients with chronic mountain sickness and normal vertebral magnetic resonance spectroscopy; to investigate whether there is a difference of vertebral body magnetic resonance spectroscopy in chronic high altitude disease patients with vertebral body magnetic resonance spectroscopy and normal healthy adults.Methods: Collect 15 cases of patients with chronic high altitude disease and 15 cases of clinically confirmed cases of sex, age, living altitude matched normal volunteers(control group), using Holland Philips Achieva3.0T superconducting magnetic resonance scanner, equipped with a special spine coil and postprocessing analysis software, the first lumbar transverse, sagittal, the conventional coronal scanning, using single voxel spectroscopy(SV) and spatial positioning point resolution spectrum(PRESS) sequence of two groups of patients with L3 vertebral spectrum acquisition, spectrum processing workstation in analysis of the software to generate MRS images, waveform was observed in the two groups of MRS, lipid peak area ratio and the water peak the two groups were calculated under the vertebral bone marrow(LWR) and fat percentage(FF%), and then used statistical methods to a comparative analysis of two groups of metabolic compounds.Results: Chronic altitude disease group and normal control group H-MRS vertebral vertebral body were showed two peaks, namely water peak and peak fat.Compared with the normal control group, chronic disease group lipid peak plateau vertebral body decreased, the water peak increased significantly.Chronic mountain sickness group average LWR for 1222, average FF, normal control ertebra group average LWR for, average FF, chronic plateau sickness group LWR and FF was significantly lower than that of the normal control group(t =, P < 0.05 and T =, P < 0.05), the difference has statistical significance.Conclusion: The CMS group and normal control group of vertebral MRS findings has certain characteristics and H-MRS can no a quantitative analysis of chronic high altitude disease of vertebral body and normal control group of the vertebral body fat and water changes, to provide reference information for the clinical study of in vivo vertebral biological metabolism.