The Role Of AR-V7 In Prostate Cancer And The Recent Progress Of Target Therapy

Background: Prostate cancer is one of the most cmmon cancer in malignant tumor of urology, and androgen receptor(AR) plays an important role in the development of prostate cancer.It promotes development or metastasis of prostate cancer by regulate the expression of target genes. Endocrine therapy or androgen deprivation therapy(ADT) has been regarded as the classic therapy to advanced prostate cancer. However, during treatment of prostate cancer, resistant often be occurred and relapse with incurable and lethal castration-resistant prostate cancer(CRPC)invariably. Although the androgen level is suppressed, but the AR signaling pathway still plays a vital role in CRPC. The study found that AR-V7 has a role in promoting AR signaling pathway activation. Objective: Exploring the role of androgen receptor splice variant 7(AR-V7) in development and resistantance of prostate cancer and the recent progress of target therapy about prostate cancer, in order to provide new targets for drugs and overcome resistance during treatment. Methods: Research articles of nearly five years about roles of AR-V7 in prostate cancer and progress of target therapy of prostate cancer by using Pubmed, Wanfang database, VIP, CNKI and other databases. Summarizing informations and writing a review after reading. Results: The expression of AR-V7 contributes to development of prostate cancer and resistance of chemotherapy and ADT treatment by several mechanisms, including activating AR signaling pathways and promoting expression of intratumoral autocrine factors. AR-V7 plays an important significance in the occurrence and development of prostate cancer and drug resistance.