Study Of Characteristic Of Patients With Acinetobacter Baumannii Infection And Risk Factors For Bloodstream Infection Caused By Acinetobacter Baumannii

ObjectiveTo analysis the clinical characteristic, epidemic trend and drug resistance evolution of patients with acinetobacter baumannii infection, it can provide reference for using antibiotics properly and controlling nosocomial infection; To explore the risk factors for acinetobacter baumannii bloodstream infection, it also can provide a basis for reducing the morbidity and mortality of acinetobacter baumannii bloodstream infection. MethodsWe collected clinical cases of 1058 patients with acinetobacter baumannii infection and 98 patients caused by acinetobacter baumannii bloodstream infection between January 2010 and December 2015 at the first affiliated hospital of Jinan University. The clinical data was retrospectively analyzed respectively. According to 30 days prognosis in patients caused by acinetobacter baumannii bloodstream infection are divided into death(39 cases) and survival groups(59 cases). The data was analyzed with the univariate and multivariate logistic regression analysis.Results 1. 1058 patients with acinetobacter baumannii infection mainly distributed in ICU and followed by respiratory department. The specimen types mainly from respiratory tract specimens, followed by blood samples. The drug resistance rates of acinetobacter baumannii are rising year by year. In general, it is 50% above, among them the resistance rates of MEM and IPM are 57.8% and 70.8%.2. 98 patients with acinetobacter baumannii bloodstream infection, average age(63.57±17.34) years old, average hospitalization days(35.55±42.86) days, mainly distributed in ICU and followed by cardiology department. The majority of patients with respiratory and cardia-cerebrovascular diseases.3. The univariate analysis showed that risk factors associated with acinetobacter baumannii infection include APACHE II sore, invasive manipulation, use of broad-spectrum antibiotics and immunosuppressor, bacterial resistance, infected with other parts or microorganisms, combination of respiratory system diseases, hematodialysis, total leucocytes(P<0.05), while multivariate logistic regression analysis indicated that 2 independent risk factors were screened out from the 10 factors, including APACHE II score and bacterial resistance(P<0.10).Conclusions 1. The rates of morbidity and drug resistance caused by acinetobacter baumannii infections increased year by year. The specimen type mainly from respiratory tract specimens, ward is mainly distributed in the ICU. 2. Patients with bloodstream infection caused by acinetobacter baumannii are in a critical condition and high mortality, and the independent risk factors are APACHE II score and bacterial resistance.