| Background:As a patient who had ulcerative colitis,a safe and effective treatment is urgently required. It was known that granulocyte and monocyte adsorption apheresis may be an important role for ulcerative colitis.Thus, a meta-analysis was fulfilled.Methods: Medline,the Cochrane controlled trials register and VIP were used to identify randomized controlled trials comparing granulocyte and monocyte adsorption apheresis with corticosteroids, comparing 10 sessions with 5 sessions apheresis,comparing intensive with conventional apheresis in patients with ulcerative colitis and comparing granulocyte and monocyte adsorption apheresis with conventional medicines in remission maintenance rate.Results: 14 randomized trials were enrolled. According to pooled data, compared with corticosteroids,granulocyte and monocyte adsorption apheresis is effective for inducing clinical remission in patients with ulcerative colitis.Whereas,the efficacy of granulocyte and monocyte adsorption apheresis was not dependent on the number of apheresis sessions. The intensive apheresis is more effective for inducing clinical remission than weekly apheresis. The rate of adverse events by apheresis was significantly lower than that by corticosteroids.The remission maintenance rate was higher in granulocyte and monocyte adsorption apheresis compared with conventional medicines in the asymptomatic UC patients.Conclusion:Our meta-analysis indicates that intensive granulocyte and monocyte adsorption apheresis is a safe and effective treatment,because of the higher rates of clinical remission and response for ulcerative colitis compared with corticosteroids, as well as the higher remission maintenance rate compared with conventional medicines. |
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