The Clinical Analysis Of Children With Seizure Secondary To Tuberous Sclerosis Complex

Objective: To analyze the clinical features of the pediatric patients with seizure secondary to tuberous sclerosis complex(TSC).Methods: We retrospectively reviewed the clinical data of 38 pediatric patients with seizure secondary to tuberous sclerosis complex. The statistics was done by SPSS software for Windows.Results:(1) 38 TSC pediatric patients with seizures, 19 is males and 19 is females, 23.7%(9/38) have a family history.(2)The age of seizure onset was ranged from 1+ month to 9.3 years(The median is 7.5 months).The onset age was less than 1 year in 55.2% and exceed 3 years in only 15.8 % of all TSC patients.(3)The first seizure patterns: 19/38(50%) presented partial seizures, 9/38(23.5%) presented generalized tonic-clonic seizures, 8/38(21.1%) presented epileptic spasms,1/38(2.6%) presented absence seizure and 1/38(2.6%) presented Atonic seizures.(4)35 cases underwent cranial MRI and all were revealed with cerebral hemisphere cortical, subcortical and subependymal multiple nodules.Two cases presented Subependymal giant cell astrocytoma.(5)children with epileptic spasms or with poor seizure control have obvious mental retardation.(6)The epilepsy control rate with using one AEDs, two AEDs, three AEDs or exceed respectively is 88.9%,58.8%,0%. 5 TSC children with spasm seizure were treated with Vigabatrin, whose seizure control rate is 80%, higher than those treated with convention AEDs(control rate of 33.3%).Conclusion:(1)Cerebral hemisphere cortex, subcortical and subependymal multiple nodules or calcification contribute to the diagnosis of TSC.(2)The patients with a history of epileptic spasms and with a poor epilepsy control are more prone to mental retardation.(3)The more kind of AEDs is need, The epilepsy secondary to TSC is more difficult to control.(4)Superior efficacy for the treatment of epileptic spasms with vigabatrin in patients with TSC.