In Aged Rats With Different Sports Load On Cognitive Ability, And The Influence And Mechanism Of Hippocampal Neural VEGF\VEGI

At present our country to speed up the aging population, along with a series of social problems.Airframe ageing multisystem organ function degradation, affects the daily life behavior and quality,cognitive impairment is one of the important phenomenon. Structure and the surrounding cortex andhippocampus is closely related human cognitive ability, some factors can be benefit the gods by theorganization, in turn, affect the cognitive functions of the body. Develop good habits is necessary toimprove the cognitive ability of old age, physical exercise is now widely recognized behaviors, butlack of sports for the elderly at present stage the research on the effects of neural function in aparticular group, in view of this, this topic as the research object, to old rats to explore suitable forelderly body exercise intensity. Research is divided into the control group (C), small load exercisegroup (S), moderate load exercise group (M), big load exercise group (H), with eight weeksnon-weight bearing different load swimming training motion model is established, through the eightarm maze experiment observation group rats the cognitive abilities of related indicators, includingthe working memory errors, reference memory errors, foraging completion time. Further the use ofreal time PCR and immunohistochemical experiment examined each rat hippocampal nerve tissuethe expression of VEGF and VEGI, the results showed：1. Compared with group C, S, M group reference memory error number change is not obvious(P>0.05), group H number of reference memory error significantly increased (P <0.05); Comparedwith the group S, M, H group number of reference memory errors were increased (P <0.05).Compared with group C, group S working memory error number decreased significantly (P <0.05),group M working memory error times is no significant change (P>0.05), number of group Hworking memory errors increased significantly (P <0.05). Compared with group C, group Sforaging completion time was significantly shortened (P <0.01), M, H group foraging completiontime little change (P>0.05); Compared with group S, M, H group foraging finish time weresignificantly prolonged (P <0.01).2. Compared with group C, group S hippocampus nerve tissue VEGF expression (P <0.01),cut VEGI expression (P <0.01); Group H hippocampal neural tissue cut (P <0.01), the expression of VEGF VEGI expression (P <0.01); M group has a little influence on the expression ofhippocampal neural tissue VEGF and VEGI (P>0.05).Our results suggest in aged rats with small load movement to improve the cognitive ability isgood, this change is not big, medium load and heavy load movement is conducive to improve thecognitive ability of aging rats. This mechanism may be related to small load exercise can increaseaging rats hippocampal neural tissue cut VEGI VEGF expression, expression, and improve the stateof hippocampal neuron proliferation and nutrition supply, big load exercise group showed theopposite trend. It is recommended that suitable for old people to do more small load movement,avoid long time engaged in heavy load movement.