| With the rapid development of social economy, the human society and the degree ofactivity continue to expand the scale and the ability to take to the natural environment andthe intervened power are more and more big, the resource consumption and waste emissionsincreased, And people in recognition of the limitations of the personal and less protectioncaused a global environmental pollution. Based on the situation people began to considerenvironmental certain compounds in the potential impact on human health. Environmentprovides human air, water, food and so on, most of which carcinogenic factor contained in it,these factors through different ways to change the constitution or human cells that make up,cause cancer production. In recent years the cancer has become the main killer threat tohuman health, the next few years of cancer incidence rates will probably double. At presentour country city residents in the death rate from cancer has set up a file in the first place, so"had conducted" has become a major disease improve treatment effect, improve the qualityof life, and to save medical expenses of key factors.Many human disease and injury can be in animal model building, medicine andmedical science research and small animal experiment is closely linked. Any clinicalimaging techniques and drug testing must be first in animal experiments on the realizationand validation. In this kind of situation, multi-model small animal molecular medicalimaging equipment arises at the historic moment, it is research and development with theneeds of medical research, and it is the realization of the new drug research and hadconducted indispensable key equipment. The multi-model small animal medical imagingdevice set the molecular X-ray Tomography (Computed Tomography, CT), PositronEmission Tomography (Positron Emission Computed Tomography, PET) and Single PhotonEmission Tomography (Single-Photon Emission Computed Tomography, SPECT) threemodes of unity, is a collection of anatomical imaging, metabolic imaging multifunctionalmedical imaging equipment, including a CT equipment mainly responsible for give PET/SPECT equipment image positioning and detail analysis.This study based on Hebei university and Peking University medical images of thejoint laboratory related subject, this topic by the national major scientific instrumentsdevelopment special project (project name: small animal multi-mode molecular imagingsignificant scientific instruments and key technology research; the project Numbers:2011YQ030114) support, led by Beijing university, such as Hebei university of the country morethan ten colleges and universities, and with the implementation of the hospital.In this period, the main research contents include two parts, the first part is a smallanimal CT system design, including X-ray source and detector selection, and the overallsystem design, the X-ray light road map design; The second part is the machinecommissioning, including adjusting center, test spatial resolution and density resolution, andso on. These include:(1) combined with equipment development process, the little animalspiral CT machine of the principle structure simulation, in overall design and assessment;(2)to achieve design index of X-ray way drawing design;(3) refer to light path figure design,size of parts and modify the structure and X light source transformation detector bracketdesign;(4) the assembly commissioning, to each part size for fine-tuning, including centeradjustment, highly bottle opener adjustment, rotating center alignment, and other details toadjust;(5) through the physical model for overall adjustment effect scanning equipment forverification, until comply with the design requirements;6the key index of CT machine tests,including spatial resolution and density signal-to-noise ratio and resolution, the sensitivitytest;7using equipment to several living animals scanned, in practice verification equipmentperformance and overall effect. |
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