The Fluid-Structure Interaction Finite Element Analysis Of Lenticulostriate Artery Bleeding Mechanism

Cerebral hemorrhage refers to a non traumatic brain parenchymal hemorrhage. It has the characteristics of high incidence, rapid progression and disability mortality. Brain death is already the third fatal disease behind the heart disease and cancer. The cerebral hemorrhage cerebrovascular is the most deadly disease in the cerebrovascular diseases. The treatment of cerebral hemorrhage is mainly on the medical treatment. There is few studies on its incidence mechanism and prevention. In our country, the field of brain hemorrhage has not a completely theory to explain the occurrence of cerebral hemorrhage in its associated mechanical mechanism. So it is urgent to analysis the pathogenesis of cerebral hemorrhage with the method of hemodynamics, and it aims to provide an available reference for clinical medicine.Fluid-structure interaction analysis research and application has developed rapidly in the recent years. There are researchers calculate the Fluid-structure interaction effect of aneurysm in hemodynamic. But there are rear Fluid-structure interaction analysis of cerebral hemorrhage, especially for the lenticulostriate artery(LSA) bleeding.This work tries to establish the wall/blood interactive model between M1 segment of the middle cerebral artery and the LSA, use the special Fluid-structure interaction algorithm which combines Transient Structural in ANSYS Workbench and CFX to achieve two-way interactive calculation of structural analysis and fluid analysis. According to health human physiological state, the experiment uses the finite element method to carry out the numerical simulation in terms of the blood flow of M1 segment of the middle cerebral artery segment and the LSA. Under the given conditions of entrance and outlet of vessels' blood pressure, simulate the pressure, stresses, strains distribution and flow field distribution to build the LSA equal strength model.Firstly,under the pathological conditions of insufficiency of cerebral blood supply LSA terminal velocity slows down. under the equal strength model,, analyze the influence that LSA terminal velocity slows down to the wall of LSA. Through comparative analysis, the experiment shows that as the slowing down of the flowing velocity of the LSA, the increasing of the blood pressure within the LSA and the closer the end, the greater the magnitude of the blood pressure, it leads to a substantial increasing of the equivalent stress near the end, forming the rupture-prone points of the wall which are dangerous parts of the LSA bleeding, and the result has a high match with the clinical statistics on the cerebral arterial bleeding site.Secondly, the cerebral hemorrhage is mainly due to hypertensive hemorrhage. According to two kind of pathologies of the hypertension, and the effects of artery stenosis. It shows that the higher the blood pressure, the higher the equivalent stress, and the more likely LSA bleeding.The work studies the pathogenesis of the cerebral hemorrhage using mechanical methods. It provides a reference for clinical medicine and has a very important practical significance.