Investigated The Bonding Behavior Of P-Sulfonated Calix-[n]arenes With Some Drugs Molecules

Calixarenes, a versatile class of macrocyclic compounds possessing soft ?-donor cavities composed of benzene rings and hard oxygen cavities constructed on the hydroxyl lower rim, have been extensively investigated in recent years because of their unique characteristics in structure and properties. During the past decades, considerable efforts were made to develop various calixarene derivatives with unique structure and to study their supramolecular characteristics, the cavity can be adjusted and the conformational variability and ease of chemical modification and so on. Calixarene derivatives has become a core research scientists, in many single concern or interdisciplinary. The important factor for calixarene rapid development is the disadvantage of poorly water soluble breakthrough this year, now, calixarene supra molecular structure with the strong bonding of host-guest molecular and molecular recognition for novel host-guest compound to build a good platform.In this paper, three p-sulfonated calix[n]arene(SCn A,n=4,6,8) was investigated, using a variety of means of detection, research bonded supramolecular behavior between p-sulfonated calix[n]arene and drug molecules.The first part, a brief overview of the development process of supramolecular chemistry discipline, by the weak interaction between molecules to build a new structure and function of the system, from the instability in hard water-soluble to the current supra molecular specific molecular recognition and self-assembly. It focuses on the supramolecular construction molecular derivatized advantage breakthrough in structural stability and the water-soluble.This selection of supramolecular p-sulfonated calix[n]arene has superior water solubility and molecular recognition, sustained-release drug molecules, molecular assembly, as well as science electrochemical sensor produced are widely used.The second part, the interaction behavior of p-sulfonated calix-[n]arene with tramadol hydrochloride was investigated by fluorescence spectra, 1H NMR spectra, and theoretical calculations in aqueous solution. At the optimized conditions, the fluorescence inten-sity of tramadol hydrochloride showed positive correlation to the concentration of SCn A, which led to a validated, simple, and sens- itive fluorescence quenching method for the determination of Tramadol Hydrochloride was established for the first time. These research results were consistent with the fluorescence discussion and 1HNMR results. Density functional theory calculations were carried out to propose the possible molecular inclusion model of TR with SC4 A. The inclusion stoichiometric ratio of 1:1 was verified, and the inclusion constant was estimated. Moreover, the interaction based on SCn A superstructure provided has promising potential for therapeutic monitoring and pharmacokinetics and clinical application.The third part, the p-sulfonated calix[n]arene(SCn A, n = 4,6,8) as a chemically modified electrode modifier for modified gold electrodes prepared sulfonated calixarene modified electrode(SCn A-Gold). Cyclic voltammetry was used in the experiment was the detection means for analysis determined Tramadol Hydrochloride,oriented research p-sulfonated calix[n]arene-bonded on the gold electrode electrochemical recognition. Determine the optimum deposition conditions and the determination of interference in tramadol hydrochloride practical application analysis. SCn AGold modified electrode to give the best detection limits, and in the practical application also reflects the satisfactory recovery and high sensitivity. Moreover, the interaction based on SCn A supers tr- ucture provided has promising potential for therapeutic monitoring and pharmacokinetics and clinical application.The fourth part, SC4A-Gold modified gold electrode substrate for the best to discusses the interaction of the p-sulfonated calix[4]arene with tramadol hydrochloride and acetaminophen using the electrochemical methods,established more sensitive and efficient supramolecular electrochemical means of identification. In the daily medication, tramadol hydrochloride and acetaminophen usually use complementary, and have an electrochemically active, but acetaminophen non-fluorescent substance can not used fluorescence titration using electrochemical method, which is the origin-al idea of this experiment. SC4A-Gold modified gold electrode can be simultaneously bonded Supramolecular behavior of the two drugs. 1H NMR spectroscopy data further validate they are obvious displacement, space matching effect, hydrophobic interactions and the role of the charge are played an essential influence for the interaction.