An Investigation On The Dissolution Increase Of Paracetamol By Solid Dispersion And Recrystallization

Paracetamol is used clinically to treat common cold. The poor water solubility of paracetamol prevents the in vitro dissolution and in vivo absorption after oral delivery. For the purpose to improve the solubility of paracetamol, the solid dispersions of this drug with water soluble carriers were prepared. Re-crystallization technique was also used to improve the solubility of paracetamol by decrease its particle size.PEG4000, Poloxamer-188 and Solutol-HS-15 were used as hydrophilic carriers in the preparation of solid dispersion by mean of melting or co-precipitation. According to the XRD results, paracetamol still exist in the form of crystal in all the solid dispersion. The in vitro dissolution was improved for the paracetamol in solid dispersion if compared with the raw crude paracetamol.The fine particle of paracetamol with the diameter around 5?m was prepared by re-crystallization technique according to the solubility change with the change of temperature. According to the XRD results, paracetamol still exist in the form of crystal in all the solid dispersion. The in vitro dissolution was improved for the paracetamol in solid dispersion if compared with the raw crude paracetamol. There was a significant difference in the in vitro drug release especially in the first 10 min. That difference obtained in the medium of 25? was greater than that in the medium of 37?.Capsule with the refined paracetamol was prepared and its in vitro dissolution was measured and compared with the marked product containing paracetamol. As the result shown, there was a improved dissolution for the capsule prepared with the fine powder of paracetamol.The work in the experiment could be a reference for the quality improvement of the oral dosage forms containing paracetamol or the other poorly-water soluble drugs.