Reduction Technology Of Terramycin Bacterial Residue By Alkaline Hydrolysis Enhancement And H₂O₂ Oxidation

Antibiotics bacterial residue is a kind of special hazardous waste,which has large production and high environmental risk.Thus its reasonable and effective treatment and disposal is a key issue for pharmaceutical companies.Physical-chemical reduction of terramycin bacterial residue using alkaline hydrolysis enhancement and H₂O₂ oxidation was carried out in this study.Treatment process and control parameters determined in the study would provide the theoretical and technical support for the treatment and disposal of antibiotic bacterial residues.The main research results were summarized as follows.1)The results of the alkaline/thermal treatment process of terramycin bacterial residue showed that the optimum parameters were moisture content of 98%,temperature of 120°C,the reaction time of 120 min and NaOH dosage of 0.09 gNaOH/gTS.The concentration of SCOD in solution increased from 607.11 to 12 190.48 mg/L,which showed the dissolution rate of SCOD reached 55.50%.And the concentration of SS in terramycin bacterial residue decreased from 18.33 to 10.36 g/L,which showed the reduction rate of residue reached 43.48%.2)The results of alkaline/ultrasonic treatment process of terramycin bacterial residue showed that when the optimum parameters were moisture content of 98%,ultrasonic energy density of 2.4 W/m L,the reaction time of 120 min,and NaOH dosage of 0.08gNaOH/gTS,the dissolution rate of SCOD and the reduction rate of bacterial residue reached 70.24% and 53.02%,respetively.3)The results of alkaline/microwave treatment process of terramycin bacterial showed that when the optimum parameters were moisture content of 98%,microwave temperature of 200°C,the reaction time of 60 min,and NaOH dosage of 0.06 gNaOH/gTS,the dissolution rate of SCOD and the reduction rate of bacterial residue reached 56.10%and 62.08%,respetively.4)On the basis of alkaline hydrolysis enhancement,the experiment of secondary reduction by H₂O₂ oxidation was carried out.The result showed that when the dosage of H₂O₂ of 3%,and pH value of 13,the secondary reduction rate of residue after alkaline/thermal-H₂O₂,alkaline/ultrasonic-H₂O₂,and alkaline/microwave-H₂O₂ treatment reached 17.17%,17.20% and 11.77%,respetively.And the general reduction rate of terramycin bacterial residue were 60.65%,70.22% and 73.85%,respectively.According tothe treatment effect and economic cost,the combination process of alkaline/ultrasonic-H₂O₂ oxidation was determined to be the optimal reduction treatment process.