Study On Silver-Catalyzed Cyclization Of 2-pyridyl Alkynylcarbinols With Isocyanides

Indolizine is a commonly structural subunit in many natural products and synthetic Pharmaceuticals. Many efficient and versatile methods for the synthesis of indolizines are emerged owning to their excellent properties. We classify these methods for the synthesis of indolizines as follows:Tschitschibabin reaction, Baylis-Hillman reaction,1,3-dipolar cycloaddition and cycloisomerization of propargylic pyridines. Because of the importance of these compounds, the development of new strategies for their synthesis has great significance.Herein, we described an efficient strategy for the synthesis of indolizines via silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides. In this transformation, the starting materials are readily available, and it has a good tolerance of the functional group of the substrates.In addition, we reported the first example of chemoselective silver-catalyzed route to 2, 4-disubstitutedpyrroles from the cyclization of 2-pyridyl alkynyl carbinols with isocyanides.