The Synthesis And Application Of Ternary Metal Complexes Bearing N-hydroxyl-N'-benzoylthiourea Ligand

N-benzoylthiourea derivatives and their metal complexes have increasing attraction for a long time due to their important application of biological activities, such as antitumor, anticancer, antibacterial, etc. In this thesis, four kinds of metal complexes of N-benzoyl-N?-hydroxylthiourea derivative and CdS nanoparticles using cadmium complexes of N,N-di(2-hydroxyethyl)-N?-benzoylthiourea as single-source precursors have been synthesized. The organic ligands, their corresponding organometallic complexes and CdS nanoparticles have been characterized by using different methods. The biological activities of ligands and their complexes were investigated. The photocatalytic properties of the as-obtained CdS products under visible light irradiation were studied. The main contents of the thesis are given as follows:Chapter I: The synthetic methods and the application of thiourea derivatives, especially acylthiourea derivatives and their metal complexes were reviewed. The test method and mechanism of interaction with DNA and HSA with complexes were summarized. The synthesis and application of CdS nanoparticles were briefly reviewed. The thiourea derivative complexes as a single precursor for the synthesis of CdS nanomaterials were summarized. The application status of benzoylthiourea derivatives in chemistry and molecular biology and the synthesis of CdS nanomaterials using cadmium complexes as single-source precursors were literatured.Chapter II: N-(2-hydroxyethyl)-N?-benzoylthiourea for the synthesis and four novel ternary metal complexes of the type [M(Phen)(L1)2)](phen=1,10-phenanthroline, L1=N-(2-hydroxyethyl)-N?-benzoylthiourea, M= Cu(II), Co(II), Ni(II), Pd(II)) were synthesized. The organic ligands and their corresponding organometallic complexes have been characterized using UV–vis absorption spectroscopy, element analysis, infrared radiation spectroscopy and fluorescence spectra.Chapter ?: DNA binding and cleavage studies of synthesized complexes were conducted in detail. Vitro DNA-binding properties were studied by electronic absorption spectra and emission spectra methods. The results indicated that all of the ternary metal complex can efficiently bind to DNA via intercalation modes. The DNA binding constants for all ternary compounds are around 4 × 106 M-1. The binding propensity of the complexes to human serum albumin(HSA) was also investigated by different method to understand the carrier role in body system. Agarose gel electrophoresis study revealed that the metal complexes could cleave super coiled pBR322 DNA to a nicked form in the absence of external agents. In vitro antibacteria study showed that the metal complexes also possessed different antibacterial activities. All complexes had a good activity against gram positive and gram negative bacteria. Of four metal compounds, the complex of copper always exhibits the strongest biological activity.Chapter ?: Cadmium sulphide(CdS) nanoparticles were synthesized by chemical precursors using N,N-di(2-hydroxyethyl)-N?-benzoylthiourea as sulphide ion sources through a homogeneous precipitation technique. The obtained CdS nanoparticles was characterized by the field emission scanning electron microscopy(FESEM), transmission electron microscopy(TEM), X-ray diffraction(XRD), UV-visible Dif-fuse Reflectance spectroscopy(DRS), Fourier transform infrared spectroscopy(FTIR). The synthesized nanoparticles have particle sizes of 3-4 nm with hexagonal crystalline structures. The CdS nanoparticles exhibit much higher visible-light photocatalytic activity for degradation of methylene blue.