Study On The Synthesis Of Alkenyl Sulfide And N-Containing Heterocyclics By Radical Coupling Reaction

Radical coupling reaction act as an important method for C-O,C-S,C-N bond formation in organic synthesis.Alkenyl sulfide,phenanthridine and quinoxalinone derivatives are important structural units in numerous alkaloids and natural products with significant biological activity and extensive medical applications.This thesis focuses on the synthesis of alkenyl sulfide and nitrogen-containing heterocyclic,and consists of the following four parts:(1)The recent research on alkenyl sulfide and nitrogen-containing heterocyclic has been reviewed.(2)A copper and iodine-mediated C-H oxidative sulfenylation of olefins with diaryl disulfides has been developed for the stereospecific synthesis of E-vinyl sulfides.The reaction conditions are simple and high atom-economy.(3)An iron-promoted tandem carboxamidation and cyclization between aryl isonitriles and formamides has been developed for the synthesis of phenanthridine-6-carboxamides with excellent functional group tolerance.(4)A tanden nitrosation and cyclization between trifluoromethyl acetamide and tert-butyl nitrite has been developed for the synthesis of quinoxalinones.This reaction was conducted under mild conditions with moderate to excellent yields.