Synthesis And Biological Activity Of Glucose Derivatives

Glucose and its derivatives are important elements of higher animals sugar chain structure of the animal and plant tissues with high affinity,low toxicity ect..When introduced into plant fungicide,they could increase the affinity and reduce the toxicity of the drug,and reduced the residual degradation.In recent years,research on glucose and its derivatives have received much attention.In this thesis,a series of derivatives of glucosamine was synthesized from glucosamine hydrochloride and substituted benzoic acid.Some of them were tested the plant induced resistance,the results showed that: the compound N7 displayed the good control effect against Corynespora cassiicola and Phytophthora infestans at 50 mg/L respectively,which is a litter lower than that of 75% chlorothalonil WP and 50% dimethomorph WP;compound N9 exhibited better control effect against Pseudomonas syringae pv.lachrymans than that of Zn thiazole 20% SC.Meanwhile,another series of glucose ether derivatives were synthesized from phenol and glucose.The primarily plant induced resistant results indicated that the compound F4(79.70%)and F11(77.66%)possessed better control effect against Botrytis cinerea than of control 50% procymidone WP(64.50%)at 50 mg/L.Among them,compound F10 and F15 exhibited moderate activity against Corynespora cassiicola.For the Colletotrichum orbiculare,compounds F1,F2,F3 and F6 displayed moderate activity.All the compounds exhibited weak activity against Pseudomonas syringae pv.lachrymans,except compound F14.Finally,this paper a amino ester derivative of glucose was designed,because of the time it have not been able to get the final product.In this paper,all the compound structures were characterized via ~1H NMR and FTIR spectrometry,and the melting point of each compounds determined.