Research Of Nanostructure Lipid Carriers Coencapulated Of Sun Filter

In this study, emulsification-ultrasonication method was used to prepare the nanostructured lipid carriers. The formulation was consist of UV filter butylmethoxydibenzoylmethane (BMBM), emulsifier hydrophilic surfactant sodium stearoyl glutamate (SG), caprylic/capric triglyceride (GTCC). The effect of the solid lipid's structure on nanostructured lipid carriers (NLCs) encapsulated with sun filter was investigated at first. In the study of the effect of fatty alcohol's chain length on NLCs, the particle size, PDI and pH was increasing with the increase of chain length, while the Zeta Potential (ZP) and protect ablility was decreased. High Entrapment efficiency indicated that most of the sun filter was encapsulated in the NLC. In the study of the effect of fatty acid's chain length on NLCs, the particle size, PDI and ZP was decreased with the increase of chain length, and the pH value mean the system was neutral. High Entrapment efficiency indicated that most of the sun filter was encapsulated in the NLC. In the study of the effect of solid lipid's hydrophilic radical on NLCs, all the NLCs had a high Entrapment efficiency. When the solid lipid was fatty alcohols, the NLCs had a smallest particle size, a best protect ability. When the solid lipid was fatty acids, the NLCs had a highest ZP, a worst protect ability. When the solid lipid was esters, the NLCs had a largest particle size, a lowest ZP, and the pH value mean the system was neutral.Transmission electron microscopy (TEM), particle size, zeta potential (ZP), UV Performance, differential scanning calorimetry (DSC), wide-angle X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR) were used to investigated the NLCs' physicochemical properties. As a result, the SEM and TEM shown the NLC particles was spherical and in homogenous shading. From DSC and XRD, polymorphic behaviors occurred.Finally, the effect of solid lipid's structure on NLCs vitro release ability and photostability was studied.In vitro release ability study, the NLCs released faster when the solid lipid had a better hydrophilic property or had a poorer stability. The NLCs all had a good storage stability except the NLCs with fatty acids.In photostability study, the NLCs had a good photostability when the solid lipid had a strong polarity or had a good stability. The chain length of solid lipid had no significant influence on NLCs photostability.