The Study Of Click Chemistry In Electrospinning And Its Application In Formation The Nanofiber Hydrogel

The intelligent fiber materials are those who can response to the environment change or the stimulations. Fibrous hydrogel is the most widely used in the intelligent fibers, compared with the conventional hydrogels, it has many advantages:great length-diameter ratio, high specific strength, large specific area and it can be processed into a variety of new products. Thus fibrous hydrogels have an important position in the intelligent fibers and have received more and more attention.Copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) is widely used in the"Click chemistry". The reaction with manifest advantages, such as mild reaction conditions, high yield and easy product isolation. Therefore, CuAAC is one of the most widely methods used in the synthesis of polymer network structure. In this paper, Cu(I) species can be generated with copper nanoparticles with a comproportionation reaction as the catalyst in the "click chemistry". Electrospinning is the only way to manufacture fibers directly and continuously. The polymeric fibers hydrogel prepared from electrospinning simulate the structare and function of extracellular matrix to a certain extent. Then electrospinning is an important method in the tissue engineering technology, it has opened up a new way for the tissue engineering materials and has attracted widespread attention and study. Thus the preparation of well performing fibrous hydrogels via electrospinning and in-situ "Click Chemistry" has great significance.In the paper, the well performing fibrous hydrogels have prepared via electrospinning and in-situ "Click Chemistry". Initially, the copper nanoparticals were prepared by one-step chemical method, and the linear functional PEG derivatives with pendant alkynyl groups (PEGn(C=CH))m and with azido moieties (PEGn(N3))m were synthesized via epoxide-amine chain-extension reaction between poly(ethylene glycol) diglycidyl ether (PEGDGE) and propargylamine/1-azido-3-aminopropane. Subsequently, the PEG-based FH's were fabricated from the blends of poly(ethylene oxide) (PEO) and the functional PEG derivatives via electrospinning and in-situ CuAAC reaction using the encapsulated copper nanoparticles as the catalyst. The blends of PEO and the functional PEG derivatives were also utilized to prepare the microscopic hydrogels (MH's). The properties of the FH's and MH's were investigated by scanning electron microscope (SEM) observation, swelling ratios, differential scanning calorimetry (DSC) and in vitro degradation. The copper nanoparticles-encapsulated FH's and MH's were further used to catalyze the CuAAC reaction in a small molecule model. The reusability of the FH's for CuAAC reaction was also studied.