Studies On Preparation And Property Of D-Tryptophan And Quinolone With ?-Lactam Structure

As an important amino acid, D-tryptophan has been widely applied in the food and pharmacy industry. It is valuable to explore a new production process, which is simple process, low cost and environmentally friendly.A large number of experiments show that separation method, resolution agent, material ratio, reaction temperature and time have different effects on the resolution of DL-tryptophan. The optimized asymmetric transformation method:Reaction 10.2g L-tryptophan with 14.32 g D-DBTA at 90? obtains D-tryptophan with specific rotation of 28.3 and yield of 63.18%.Quinolone and ?-lactam antibiotics both are important antimicrobial agents, which are used widely in all kinds of infectious disease. With the increasing resistance of bacteria to antibiotics, it is of great significance for human health to develop new antibiotics.A new compound compounds with quinolone and ?-lactam structure was synthesized from 6-APA and an quinolone that was prepared from 4-fluoro aniline and diethyl 2-(ethoxymethylene)malonate by four steps reaction. The new compound compound with quinolone and ?-lactam structure was characterized by melting point, IR,1HNMR and MS; the synthetic routes were also optimized in some degree. Antimicrobial activities of the new quinolone-?-lactam compound to 3 microorganisms were studied by using double dilution methods, which was compared with three control drugs. The experimental results show that the new compound has good antimicrobial activities against 3 microorganisms, especially against staphylococcus aureus.