Synthesis And Characterization Of Interpenetrating Network Hydrogels Of Chemical Cross-linked And Organ-metallic Complexed Networks

The hydrogels are three-dimensional cross-linked polymeric network with ability of absorbing and retaining large amounts of water without dissolving. The hydrogels with a topology structure forming by two or more polymers interpenetrating entanglement with each other were defined as Interpenetrating network (IPN) hydrogels. Usually IPN technology was attained by chemical way to achieve physical blending. Compared with conventional hydrogels, interpenetrating network hydrogels have a variety of excellent performance due to the synergy between components, which can be an ideal biomaterial.Click Chemistry is a method which is able to quickly synthesize large number of new organic compounds. As the "click chemistry" method has various advantages, it has been widespread concerned since it was proposed at the beginning. Reactions of "Click chemistry", the copper (I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) is the most mature cycloaddition reaction, which has been widespread concerned by many scientists.In this paper, interpenetrating network hydrogels with improved overall performance were prepared via the combination of chemical crosslinking and metal ions complexation reactions. The first layer of the network was formed by polyethylene glycol derivatives containing pendant alkynyl groups (PEG11(C?CH))x(x?3) or polypropylene glycol derivative containing pendant alkynyl groups (PPG9 (C?CH))x(x?3) reacted with polyethylene glycol derivative containg two azido PEGn(N3)2 by click chemistry method. The second layer of the network was formed by polyethylene glycol derivative containing dopamine group (PEG (DA))z(z?6) complexed with iron ion. IPN hydrogels were formed by the combination of the two layers networks. Chemical structures of the synthesized compounds were characterized by 1H NMR, FT-IR and GPC. The properties of the hydrogels were characterized by SEM, TGA, DSC, swelling ratio, mechanical strength, degradation experiments and conducting performance and so on.