The Research Of Materials Detected Of Small Biological Molecules Based On Polyoxotungstate

Objective Our aim in this thesis is to synthesize a series of polyoxotungstate hybrids functionalized by metal-organic complex and investigate their catalytic activity for small biological molecules. Among these compounds, we will screen out polyoxometalate materials with high sensitivity and selectivity and provide a new approach to new biosensors for small biological molecules.Methods The metal-organic complex functionalized polyoxotungstate hybrids have been synthesized by conventional method in water solution and hydrothermal method, structurally characterized by single crystal X-ray diffraction, infrared spectrophotometer and elemental analysis. The catalytic properties of polyoxotungstate hybrids for H2O2 have been monitored by UV-vis spectrophotometer.Results Three novel metal-organic complex functionalized polyoxotungstate hybrids were designed and synthesized and a series of polyoxotungstate compounds were synthesized by the references. Electrochemical response of these compounds for H2O2 and dopamine were explored. Both compound 1 and copper complex functionalized tungstobismuthates show better sensing performance for H2O2 by comparative study of catalyst activity. For compound 1, the detection range of hydrogen peroxide is 0.2⁷ ?mol?L^-1 and the detection limit is 0.39 ?mol?L^-1. While for copper complex functionalized tungstobismuthates, the detect range for hydrogen peroxide is 1⁵0 ?mol?L^-1, and the detection limit is 0.12 ?mol?L^-1. For dopamine sensing, copper complex functionalized tungstobismuthates also show lower detection limits.Conclusions?1? The suitable solvent ratio and pH of the reaction solution are both the key factors in synthesis of compounds 1³.?2? For catalytic reaction for H2O2, the polyoxotungstate with larger radius of heteroatom and stronger reducibility shows better electrochemical catalytic activity with lower detection limit. Also, the polyoxotungstate with larger radius of the modified metal cations and stronger reducibility shows better catalytic activity with lower detection limit.?3? For the detection of dopamine, polyoxotungstate shows low catalytic activity. Only copper complex substituted tungstobismuthates show lower detection limit.