Effect Of Coix Seed(Coix Lacryma-jobi L.)and Rice Bean(Vigna Umbellata)Soup On Hyperlipemia Mice

With the improvement of people's living standards,the Chinese diet changes,resulting in a sharp rise in the incidence of hyperlipidemia.At present,the Coix seed(Coix lacryma-jobi L.)research concentrated in the study of anti-tumor component,and its products has been industrialization,and enter the international market.Coix seed is a traditional Chinese medicine commonly used as drugs,and coix seed extract research is still in the exploratory stage,and its application is almost blank.In our study,hyperlipidemia mice were used as model animals to explore the hypolipidemic effect of Chinese diet Coix seed(Coix lacryma-jobi L.)and rice bean(Vigna umbellata)Soup;Effect of the soup on hyperlipemia mice were detected through the observation of weight,hyperlipidemia,organs and blood lipid level regulation and other aspects of mice.The methods and results in our study are as follows:Mice were divided into seven groups: control group,model control group,medicated Coix seed and rice bean Soup with low,medium and high dose group,rice bean soup,barley soup to slag group.In addition to the control group to the normal diet,the other groups rats were fed with high-fat diet;the treatment groups were given corresponding drugs by gavage,control and model groups were given normal saline.Five weeks later,rats serum were collected and detected.(1)serum lipids(TCHO,TG,HDL-c,LDL-c)content.(2)The content of NO in serum.(3)the changes of body weight,the liver and spleen index and liver pathological changes were observed.The results of the study showed that diet can protect the liver and spleen,wherestatistical difference in the liver index was significant(P < 0.01)between low dose group and model group;and the spleen index in low dose group increased significantly(P < 0.01)compared with model group,that the diet can reduce triglyceride(TG)and total cholesterol(TCHO)level,where the content of TG and TCHO in serum of low dose group is lower than the model group,that the diet has protective effects on arteries,where atherosclerosis index(AI)of each treatment group were significantly lower than that of model group,that the content of NO in low dose treatment group reached 17.28 ?mol/L,which was significantly higher than that of model group(11.25 ?mol/L).The result shows that the diet had protective effect on blood vessels,which could reduce the incidence of atherosclerosis.Moreover,barley rice bean can upregulating the content of IL-6: The content of IL-6 in middle dose group reached 67.21 pmol/L,while it was only 36.6 pmol/L in the model group.Therefore,Coix seed and rice bean Soup with low dose group can reduce the blood fat diet,protecting vascular intima and improving organs function.But it has side effect of promoting the IL-6 up regulation of inflammatory factors.