Study On The Regulation Of Glucose And Lipid Metabolism By Herbal Teas

Hyperlipidemia shows lipid components abnormal increased in serum,causing metabolic syndrome. High blood sugar is the islet failure, insufficient insulin secretion and insulin resistance. In recent years, there have been many researches of the effects of hypoglycemic lipid-lowering of tea, flowers and their ingredients. But the exact mechanism of action is still not clear.In this paper, black tea, fu brick and Liupao tea were mixed with chrysanthemum, mint, gardeniaaccording to a certain proportion separately to produce several kinds of herbal tea. No.1, No.2 and No.3 herbal tea were selected to research the regulation of the herbal tea on glucose and lipid metabolism of mouse and genes respectively. 1 Herbal tea extracts could reduce blood lipids in mice with high blood lipidsDifferent doses of different herbal tea were fed to hyperlipidemia mouse induced with high-fat diet. Food intake changes and serum lipid levels, weight gain, liver pathology and lipid metabolism-related gene expression and other related indicators of the mouse were observed after drinking herbal tea, The influence of three kinds of herbal tea's extract on lipid metabolism on hyperlipidemic mouse was discusses. The results of systematic research are as follows:? On the end of the fourth week, in addition to No.1 and No.2 high-dose, food intake of the other four groups were declining. Compared with the model group, all mouse intervened by herbal tea could slow weight increasing, especially No.1 and No.2 high-dose.? Compared with the model group,No.1 low and high dose,and No.2 high-dose could significantly reduce hyperlipidemia mouse's TC level in serum;No.1 high-dose and No.2 low-dose could significantly reduce hyperlipidemia mouse's TG level in serum, No.2 high-dose No.3 low-dose could reduce hyperlipidemia mouse's TG level in serum; 3 kinds of herb tea could significantly reduce LDL and improve HDL level in serum.? Three kinds of herbal tea could protect the liver by reducing hyperlipidemia and the degree of degeneration of liver fat. The high dose groups were better.? Herbal teas inhibited cholesterol acyltransferase (ACAT1) partly,3-hydroxy-3-amyl methyl malonyl coenzyme A reductase (Hmgcr) and diacylglycerol acyltransferase 1 (DGAT1) gene expression of herbal tea part, enhanced cholesterol 7 alpha hydroxylase (Cyp7 ? 1) gene expression partially and decreased the levels of TG and TC, reduced lipid deposition in the liver. 2 Herb tea extracts could reduce blood sugar in mice with high blood sugarMouse hyperglycemia model was successful by STZ. The mouse wereadaptive fed for a week.Mouse were fed the basal diet.Different doses of different herbal tea were fed to hyperglycemia mouse. Food intake changes and serum lipid levels, weight gain, liver pathology and sugar metabolism-related gene expression and other related indicators of the mouse were observed after drinking herbal teas. The influence of three kinds of herbal tea's extracts on sugar metabolism on hyperglycemia mouse was discusses. The results of systematic research were as follows:? Blood sugar levels ofsix groups were declining, especially ever high-dose.The food intake of six Herbal tea groups are declining,especially No.1 low-dose; in addition to No.1 high-dose,other five groups are declining,especially No.1 and No.2 low-dose.?Compared with the model group,No.1 low-dose and No.3 high-dose could significantly increase hyperglycemia mouse's GCK level in serum,No.2 low-dose also could increase hyperglycemia mouse's GCK level in serum.Six groups could significantly increase hyperglycemia mouse's INS level in serum.?Three kinds of herbal tea could protect the liver by reducing hyperlipidemia and the degree of degeneration of liver fat. No.2 low-dose, No.2 high-dose and No.3 high-dosegroups were better.?Herbal teas partially inhibited fatty acid synthetase (Fas) and glucose-6-phosphatase G-6-pase (G6PC) gene expression, partially enhanced Pancreatic and duodenal homeobox 1 (PDX-1) and glycerokinase(GK) gene expression and increase the levels of GCK and INS, reduced lipid deposition in the liver.