Efficient Methods For Synthesis Of Trisubstituted Indolizines

There are four parts in this dissertation.The first part is the introduction of heterocyclic compounds and defferent methods for synthesis of indolizine and overview of reactions of bromoenals.The second chapter contains two parts.In the first part,three-substituted indolizine compounds was achieved by the use of bromoenals and 2-substitued azaarenes as the starting materials promoted by cesium carbonate.Using this method,we can synthetize trisubstituted indolizines with high yields.We can also synthesize pyrrolo[1,2-a]pyridines,pyrrolo[1,2-a]quinolines and imidazo[1,2-a]pyridines in modest yields.This method has some advantages such as metal-free,no oxidant,no catalyst,simple starting material,simple operation,rapid reaction and good compatibility with functional groups.In the second part,a Cu-catalyzed[3+2]cycloaddition of ethyl 2-(pyridin-2-yl)acetates with(E)-chalcones for"one-pot" synthesis of indolizines in modest to high yields has been developed.This strategy uses an environmentally friendly oxidant and inexpensive characteristics.The third part is that we designed and synthesized some compounds to test their anti-tumor activities based on our synthetic methods and pervious work.The fourth chapter is the summary of this thesis,including two efficient synthetic methods for trisubstituted indolizine compounds and their application for synthesis of molecules containing anti-tumor activities.