Synthesis Of 2-aminopyrazine Derivatives

The 2-aminepyrazin derivative is a very important pharmaceutical intermediate of many medicines. In this paper, three 2-aminepyrazin derivative is prepared as a material of 2-cyanopyrazine. Firstly, the 2-aminopyrazine was prepared by one-pot method via rearrangement and hydrolysis reaction using 2-cyanopyrazine as a material. Then 5-bromopyrazin-2-amine and 3,5-dibromopyrazin-2-amine was synthesized using NBS as a bromating agent. All these above compounds were identified by 1H-NMR and MS. Meanwhile, the above preparation parameters were optimized. According to the prepared technological conditions, the amplificatory experiment was performed. This method has some advantages of cheap materials,simple operation, lower environment pollution, a gentle reaction conditions and higher application value for the industrial production.