The Study Of The Thermodynamic Properties Of Tri-(hydroxymethyl)aminomethane And Polycrystalline Medicine In Nanopores Materials

To extend the use of phase change materials(PCMs)of those with good performance,tris(hydroxymethyl)aminomethane(THAM)is embedded in silica gels(SG)(pore diameter,d = 15~100 nm),and in controlled porous glasses(CPG)(nominal d = 12~100 nm).The THAM/SG and THAM/CPG composites are characterized by SEM and XRD.Latent heat storage performance of THAM/SG and THAM/CPG is investigated using differential scanning calorimetry(DSC),showing size-dependence of phase transition temperature,enthalpy change and supercooling.THAM in the nanopores displays stable transition temperature and heat storage capacity in a short-term thermal cycling.The bulk and the nano-sized THAM own the same diffraction patterns.The encapsulation of phase change material in nanoporous media is a promising way of tuning the thermal energy properties of those ideal PCMs for use in a wider range of temperature.At the same time,we hope to change the crystal orientation and crystallinity of polycrystalline drugs through nanoscale aperture limit function.Eventually we can increase the crystal type proportional to improve efficacy of the drug and reduce the cost.The main content of this work as follows:1.A series of pore diameter of SG and CPG were used as the frame structure.The filling rate of the composite material THAM with good performance of heat storage and temperature adjusting was no less than 80%.The composite material THAM was prepared by solution-impregnation method.2.The pore size of SG ranges from 6 nm to 200 nm and the CPG aperture ranges from 12 nm to 100 nm,compared with the bulk THAM,two kinds of phase transition temperature and enthalpy of composites in the heating process change into regularly decreases with the smaller pore size decreases.In the SG composite,the transition temperature of 6nm composite is 45 K lower than the bulk,and In the CPG composite,the transition temperature of 12 nm composite is 8 K lower than the bulk.?T and ?H in two kinds of composite fits in a linear equation.3.We can see the main functional groups,morphology and the parameters of crystal cell through SEM,IR,XRD.The chemical properties of THAM in SG pores have not changed,just because the nano-size limits space thermal storage properties.4.The thermal cycle several times(?10),the phase transition temperature and enthalpy show the stable cycle performance,which shows that the composite heat storage material possess good cycle performance.5.We made tolbutamide,phenacetin and chloramphenicol composites materials of SG,their transition temperature changes with the change of pore diameters.Meanwhile the thermodynamic characterization of the polycrystalline medicine phenomenon was investigated.Their filling rates are from 40~50% to 70~80%.