Preparation And Application Of Multifunctional Nanoparticles Based On Ca₃?PO₄?₂

With the development of nanotechnology,the application of nanoparticles in biomedical research has absorbed more and more interests.Composite nanoparticles with a variety of functions received much attention for they can compound different nanoparticles at the same time.Calcium phosphate?CaP?is a kind of good biocompatibility and non-toxic inorganic nanoparticles,and exists in teeth and bones of the body.How to combine CaP with other functional nanoparticles to a composite nanoparticle with good dispersion and appropriate size becomes a difficult problem.This paper presents a simple and feasible method,using polyacrylic acid calcium as a template,combine with Fe₃O₄ and carbon to prepare C/CaP/Fe₃O₄ composite nanoparticles with good dispersion.Complexes containing Fe₃O₄ can be used for magnetic resonance?MR?imaging and containing carbon materials can be used for photothermal therapy.Therefore,the prepared composites canserve as a theranostic agent due to their good biocompatibility,high anti-cancer drug loading,pH/NIR dual-responsiveness,magnetism and photothermal conversion ability.Moreover,we used the same methord to combine CaP with Gd₂O₃:Eu,to synthesize Gd₂O₃: Eu/CaP composite nanoparticles with hollow mesoporous structure.As well as known,Gd³⁺-based materials can be used for MR imaging,and Eu³⁺ doped can be used for fluorescence imaging at the same time.Therefore,the obtained drug develivery composite nanoparticles have potential for multimodal imaging?MRI and fluorescence imaging?.