Research Towards Synthetic Process Of Milbemycin Oxime And Misoprostol Key Intermediate

The main content of this thesis is to study the purification and synthesis of milbemycin oxime and misoprostol key intermediates.The thesis has been divided into four parts.The first part summarizes the research progress of milbemycin oxime and its pharmacological behaviors,including the advantages and disadvantages of different routes.The second part mainly focus on the purification of milbemycin,in which two major impurity structures has been identified in the fermentation of milbemycin and measures the structures of milbemycin A3 and A4 were measured.The separation and purification of probes were discussed in terms of the major differences between A3 and A4.In the third part,the methods towards the of synthetic route of milbemycin oxime from milbemycin A3 and A4 were described.The oxidation step has been explored in depth.The fourth part summarizesthe research progress of misoprostol,and synthesis of key intermediate of misoprostol,methyl 7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)-heptanoate,from commercially available suberic acid.