Boron Trifluoride Catalyzed Conversion Of Nitriles To Amides

Amides are essentially valuable in medicinal and synthetic organic chemistry.?-keto amides in particular can be used as precursors for obtaining various heterocyclic compounds.The difluoroboron(BF2)complexes of ?-diketonates,can act as photochemical reagents.In recent years,various BF2 complexes of ?-diketonates,?-keto amides and ?-keto esters have been synthesized.However,an investigation of malonamide-type BF2 complexes is very rare.In the first study,difluoroboron(BF2)complexes were synthesized from 2-cyanodiazoacetanilides and boron trifluoride etherate.The boron trifluoride etherate serves as a catalyst as well as a reactant.In the second study,difluoroboron(BF2)complexes synthesized were successfully converted into ?-keto amides(malonamides)upon treatment with sodium acetate.Generally the methods were successful since the target products were achieved in satisfactory yields.These methods offer an efficient route to synthesize amides of the malonamide-type of compounds...