Study On Preparation Of Olefin Via Nickel-Catalyzed Reductive Coupling Of Aryl Halides With Vinyl Bromides

Nickel-catalyzed reductive coupling of aryl halides with vinyl bromides under mild conditions is described,it shows broad substrate scope, good chemoselectivity and regioselectivity. If vinyl bromide is E/Z isomer, the desired products mainly display trans configuration. The good functional group tolerance is also worth to be pointed, including electron-withdrawing group aryl halides, electron-donating group aryl halides, especially heteroaryl halides and vinyl bromides generating products in moderate to excellent yield.Furthermore,a plausible mechanism is proposed according to control experiment and Density functional theory calculations results. The important intermediate Ar-NiⅡ(L)-I was obtained successfully and verified the plausible mechanism.