Study On Ipsoiododecarboxylation Of Aromatic Carboxylic Acid And Direct Trifluoromethylation Of Aromatic

Functionalized aromatics are widely presented in pharmaceuticals,pesticides,and multifunctional materials,so the research of functionalization of aromatics is very important.Aryl Iodides and trifluoromethyl-substituted aromatic play an important role in many fields due to their special physical and chemical properties.Our research includes ipsoiododecarboxylation of aromatic carboxylic acids by one-step and direct trifluoromethylation of aromatics.The specific research contents are as follows:(1)A practical,efficient,and operationally simple strategy for the ipsoiododecarboxylation and di-iodination of aromatic carboxylic acids using inexpensive aromatic carboxylic acid as substrates,iodosuccinimide(NIS)as iodine source and Pd(OAc)2 as a catalyst is developed.This iodination or di-iodination process can be easily controlled under different reaction conditions,providing corresponding iodination or di-iodination products.Furthermore,these two reactions can be easily scaled up to gram-scale by using only 0.66 mol% palladium catalyst.This work provides a feasible way for the synthesis of iodinated aromatic.(2)Graphene oxide has special physical and chemical properties as a new material which has been widely used in the field of organic chemistry,and has become one of the research hotspot currently.Here,a practical strategy for the metal-free trifluoromethylation of arenes using the inexpensive sodium trifluoromethanesulfinate as a trifluoromethyl source in the presence of graphene oxide was developed.,This strategy provides a new way for the synthesis of trifluoromethyl substituted aromatics.