Modified TiO₂ Nanotube Arrays Load With Hydrophilic And Hydrophobic Drug And Its Release Behavior

Because of the excellent mechanical properties,a lower modulus of elasticity and good biological compatibility,titanium and its alloys are widely used in clinic as the preferred metal material for the replacement and restoration of surgical implants.However,it is difficult to make chemical bond with bone tissue due to the lack of biological activity.Surface modification has been shown to be a significant method to improve the biological performance of titanium.In recent years,TiO2 nanotube arrays were fabricated by electrochemical anodization of titanium to improve the biological activity have received considerable attention.Due to their hollow structure,the titania nanotubes arrays were used as drug delivery.The vertically aligned TiO2 nanotube arrays were fabricated by anodic oxidation in the glycerol/H2O electrolytes containing F-in this paper.TiO2 nanotube arrays can be fabricated on the surface of titanium,at the same time,because of its special hollow nanotube structure,larger specific surface area and good biocompatibility and they can be as antibacterial,anti-inflammatory analgesic drugs,inhibit bone absorption of drugs.such as,the carrier,hydrophilic ibuprofen and hydrophobic alendronate as drug models.studied on modified TiO2 nanotubes with different methods,the nanotubes of morphology under different conditions have the influence of the adsorption and release of hydrophilic and hydrophobic drug.First,TiO2nanotubes were modified by using the LBL self-assembly prepared PAA-/PDDA+ films with the layer-by-layer(LbL)assembly technique in this paper.Then,the results show that modified TiO2 nanotube array loaded alendronate via vacuum drying method.The morphology of TiO2 nanotube were characterized by FE-SEM.The TiO2 nanotube arrays were used as drug delivery for alendronate,a drug which used for inhibiting bone resorption.XRD、FTIR、TG were used to characterize the drug loading systerm.Alendronate release was investigated in PBS solution with the pH 7.4.Meanwhile,we have discussed the influence of TNTs+/PAA-/PDDA+ multilayer films,layer-by-layer assembly coating and PLLA coating on the adsorption and release of alendronate.Furthermore,TiO2 nanotube arrays were treated by hydrothermal treatment in the saturated solution of zinc nitratein this paper.Partial TiO2 nanotube arrays have changed into Zinc titanate and the walls of the nanotube thickened after hydrothermal treatment.Contrasting the loading and releasing of alendronate and ibuprofen in the TiO2 nanotube arrays before and after hydrothermal treatment,the result showed that hydrothermal treatment had obvious effect on alendronate and ibuprofen absorption,but it significantly influenced the release of alendronate.Alendronate exhibited a better sustained release from the nanotube arrays that after hydrothermal treatment.At the same time,in this paper,TiO2 nanotube arrays were fabricated by different hydrothermal time and hydrothermal solution concentration of zinc titanate content in the experiment,and discuss its influence of alendronate and ibuprofen adsorption and release...