Study On P(O)-directed C-H Aromatization And Cross-coupling Reactions With Diazo Compounds

During the past ten years,diazo compounds as the reaction partners,have great significances in organic synthesis with great application prospects,such as C-H bond,functionalization,cascade reaction and so on.Those strategies provide useful methodologies for the formation of C-C bond and C-X bond.Besides,type of P,O,O-type compounds act not only as ligand,but also Lewis base,which can act as the catalyst in the reaction.So synthetizing the P,O,O-type compounds efficiently has aroused the interest of scientists.This thesis includes the next two parts:1: We discussed the development of that the P(O)R2 group was used as directed group in application of cross-coupling reactions,and diazo compounds was used as coupling partners in C-H bond functionalization.We focus on that P(O)R2 directed,C-H bond activation and aromatization with diazo compounds.We can efficiently synthetize a series of P,O,O-type compounds in mild condition,which can achieve various derivatization.2: Diazo compounds as the most common precursors of metal carbene can react with kinds of aryl halides,which include the carbine migratory insertion process.We summarizes the developments in this area and study synthesis of P,O,O-type compounds via diazo compounds and phosphorous aryl halides.This strategy provides a new method for asymmetric synthesis.