Study On Enantioselective C-H Olefination Controlled By Dynamic Kinetic Resolution

The method of transition-metal-catalyzed direct enantioselective C–H functionalization to build a variety of different chiral compound skeletons provides a concise and highly valuable pathway in the modern organic synthesis reaction.In which,the dynamic kinetic resolution strategy has the ability to convert both enantiomers of the racemic starting material into a single optically pure product with a theoretical yield of 100% which makes it become extremely powerful and economically feasible tool for gaining access to enantiomerically chiral compounds.This paper describes the study on transition-metal-catalyzed direct enantioselective C–H olefination controlled by dynamiac kinetic resolution.This thesis includes the following two parts:Chapter 1.The development of asymmetric synthesis via dynamiac kinetic resolution in recent years is classified and summarized.The content mainly includes the introduction of different type reactions of enantioselective synthesis via dynamiac kinetic resolution.The reactions are classified by different reaction types including annulation reactions,enolate alkylation,C-H activation,amination,acylation and asymmetric reduction.Chapter 2.The enantioselective synthesis of chiral atropoisomeric biaryl phosphine-olefin compounds via P(O)R2-directed enantioselective C-H olefination by dynamiac kinetic resolution under the action of transition metal catalyst.The reactions are operationally simple,tolerate wide functional groups,and have a good ee value.This research opens a new door to the useful synthesis of new axis chiral biaryl phosphine-olefin hybrid ligands.The new method as a new power is injected into the dynamic asymmetric research field.