Selective Hydrogenation Of Nitriles To Primary Amines Catalyzed By Ni₂P

Amines were a very important compounds in chemistry and biology.They were widely used in the production of pharmaceuticals,fine chemicals,agrochemicals,polymers,dyestuffs,pigments and plasticizing agents.Existing methods for the preparation of primary amines had many disadvantages like,the requirement of toxic reagents,poor selectivity and low atom-economy.From the economic and environmental point of view,this paper studied a new method for the synthesis of high selectivity nitriles to primary amines.The selective catalytic hydrogenation of nitriles to form primary amines is demanding.It often displays crucial selectivity problems,forming imines and a mixture of primary,secondary,and tertiary amines.Hence,the choice of the catalyst and reaction conditions is imperative for obtaining high selectivity of the desired primary amines.Although heterogeneous catalytic systems for hydrogenation of nitriles,such as systems based on Ni2 P.reaction system had excellent characteristics:(1)Non-precious metal phosphide catalyst,especially Ni2 P,is not only easy to synthesize,have high activity,but is reusable and non-polluting;(2)The reaction was carried out at room temperature and a high yield in a shorter reaction time;(3)In the tandem reaction,the catalyst Ni2 P played a dual role in catalyzing the dehydrogenation of the ammonia borane and catalyzing the hydrogenation reduction reaction of nitrile or nitro at the same time.(4)Hydrogen source of ammonia borane had the advantage of high hydrogen storage density and easy handling.(5)Nitrile derivatives also had a high selectivity in the system;(6)The study showed that the system can simultaneously reduce the chemical compounds contain-NO2 and-CN to the corresponding primary amines,with the excellent conversion rate and the good chemical selectivity.