Study On Catalytic Asymmetric Domino Oxa-Michael/Michael Reaction For The Synthesis Of Chiral 3-Substituted Flavanones

In this thesis,a series of small molecule organocatalysts have been synthesized for the asymmetric domino oxa-Michael/Michael reaction of 2'-hydroxychalcone and ?,?-unsaturated ketones.After preliminary catalysts screening and reaction conditions optimizating,it was revealed that the quaternary ammonium salt phase transfer catalyst derived from the cinchona alkaloid could achieve some extent of enantioselectivities(up to 61% ee)and excellent diastereoselectivities(up to 98 : 2 dr)as well as good yields(up to 93% yield).3-Substituted flavanones with three consecutive chiral centers can be obtained.In order to get better results,further optimizing the reaction conditions are still in progress.